Exercise to the rescue.
Exercise to the rescue.
复制标题
锻炼来拯救。
DOI：
10.1113/jphysiol.2011.221879
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Calvert,JohnW
中科院分区：
文献类型：
--
作者：
Huffman,DerekM;Calvert,JohnW
Obesity and the lifestyle factors that fuel it, including poor dietary habits and a sedentary lifestyle, contribute toward the development of cardiovascular disease (CVD), which remains the leading cause of death in the developed world. Perhaps less appreciated as a CVD risk factor, but no less important, is the postprandial (PPL) response to feeding. PPL describes the transient elevation in lipids and circulating triglycerides (TGs) following a meal with moderate to high amounts of dietary fat. The hazards posed by elevated circulating TGs are well documented and include pro-atherogenic effects on the vasculature, unfavourable changes to the lipoprotein profile, and increased risk for thrombosis, among others (Alipour et al. 2008). In the laboratory, human subjects provided a high-fat test meal demonstrate a steady rise in plasma TG, which can reach peak levels approaching 2–3 times basal within 4 h, and remain elevated for up to 8 h post-ingestion. However, in the ‘real world’, things appear even more dire as individuals generally go no longer than a few hours in between meals, thus exposing themselves to repeated elevations in TGs throughout the day. But just when all appears lost, a ‘hero’has emerged in this story. Indeed, there is an extensive body of literature demonstrating that a prior bout of aerobic exercise can mitigate many of the ‘villains’ brought upon by consuming moderate to excess amounts of dietary fat. These include a significant attenuation in the PPL response following a meal and up-regulation of antioxidant defence systems in the vasculature to protect against potential damage to the endothelium during the postprandial state
