NEURONAL-TYPE NICOTINIC RECEPTORS IN HUMAN NEUROBLASTOMA AND SMALL-CELL LUNG-CARCINOMA CELL-LINES
NEURONAL-TYPE NICOTINIC RECEPTORS IN HUMAN NEUROBLASTOMA AND SMALL-CELL LUNG-CARCINOMA CELL-LINES
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DOI：
10.1016/0014-5793(92)81411-e
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发表时间：
1992-11-02
期刊：
影响因子：
3.5
通讯作者：
CLEMENTI, F
中科院分区：
文献类型：
--
作者：
TARRONI, P;RUBBOLI, F;CLEMENTI, F
A beta subunit of the neuronal nicotinic receptor, sharing 88% homology with the rat beta4 subunit, has been cloned from a human neuroblastoma cell line. The gene encoding the human beta4 subunit is expressed in association with the alpha3 gene in neuroblastoma and small-cell lung carcinoma cell lines. Patch-clamp experiments and radioligand binding assays confirm that these neuroendocrine tumor cell lines express functional neuronal nicotinic receptors. We suggest that these receptors might play a crucial role in the control of neurotransmitter and hormone secretion from neurosecretory human tumors.
