Lysozyme and cancer: role of exogenous lysozyme as anticancer agent (review).
Lysozyme and cancer: role of exogenous lysozyme as anticancer agent (review).
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发表时间：
1989-05
影响因子：
2
通讯作者：
G. Sava;A. Benetti;V. Ceschia;S. Pacor
中科院分区：
文献类型：
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作者：
G. Sava;A. Benetti;V. Ceschia;S. Pacor
使用溶菌酶制剂治疗肿瘤疾病是基于30多年的经验，使用不同的方法并显示出不同的结果，并从中得出作用机制的建议。尽管一些报告中描述了一些有趣的发现，但溶菌酶在人类肿瘤的治疗中尚未确立地位。尽管如此，许多研究已经证实了溶菌酶治疗在许多实验性肿瘤中的肿瘤抑制活性。六十年代上半叶，科学家们越来越关注溶菌酶在许多动物肿瘤体内实验系统中的抗肿瘤活性。他们都强调溶菌酶通过多种途径给药后的肿瘤抑制作用，包括与肿瘤细胞混合、瘤周和瘤内治疗，或间接全身注射和口服治疗。从这些观察结果中，可以得出至少两种可能的作用机制，两者都涉及宿主免疫反应性的激活。溶菌酶可以直接激活免疫细胞或增加肿瘤细胞的免疫原性。或者，溶菌酶可以从细菌中释放出负责免疫增强并因此具有抗肿瘤活性的物质（肽聚糖和/或多聚核糖嘧啶酸）。目前的工作将重点关注溶菌酶在癌症治疗中的使用所提供的可能性，引用文献中的证据，旨在有助于更好地了解溶菌酶在肿瘤疾病治疗中的活性和作用。
The use of lysozyme preparations in the treatment of tumor diseases is based on more than 30 years' experience, using different methodologies and showing various results from which suggestions on the mechanism of action were derived. Lysozymes have no established place in the treatment of human tumors in spite of some interesting findings described in some reports. Nevertheless, many studies have confirmed the tumor-inhibitory activity of lysozyme treatment in a number of experimental tumors. The first half of the sixties saw increased attention on the part of scientists to the antitumor activity of lysozyme in many in vivo experimental systems of animal tumors. All of them emphasized tumor inhibitory effects after administration of lysozyme by various routes including admixture with tumor cells, peritumor and intratumor treatments, or indirectly by systemic injections and oral treatment. From these observations, at least two possible mechanisms of action can be derived, both involving the activation of the immune reactivity of the host. Lysozyme can directly activate immune cells or it can increase tumor cell immunogenicity. Alternatively, lysozyme can liberate substances from bacteria (peptidoglycans and/or polyribopyrimidinic acids) responsible for immunopotentiation and therefore antitumor activity. The present work will focus on the possibilities offered by the use of lysozyme(s) in cancer management, citing the evidence to be found in the literature with the aim of contributing to a better understanding of the activity and the role of lysozyme in the treatment of neoplastic diseases.