Ventral striatum dopamine D2 receptor activity inhibits rat pups' vocalization response to loss of maternal contact
Ventral striatum dopamine D2 receptor activity inhibits rat pups' vocalization response to loss of maternal contact
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DOI：
10.1037/0735-7044.122.1.119
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发表时间：
2008-02-01
影响因子：
1.9
通讯作者：
Shair, Harry N.
中科院分区：
文献类型：
--
作者：
Muller, Jeff M.;Moore, Holly;Shair, Harry N.
大多数哺乳动物的婴儿在与世隔绝时会发声。发声促进看护者的接近，这对生存至关重要。如果在隔离前，大鼠幼鼠与其母体接触，则其隔离发声率相对于仅通过同窝仔接触进行隔离而言会增加（母体增强）。先前的工作表明，全身给予D2受体激动剂在不改变基线发声的剂量下阻断母体增强。在这项研究中，输注quinpirole（2微克/侧）到核的丘脑也阻断母体增强。与D2拮抗剂雷氯必利（4 μ g/侧）一起输注阿替宾可防止全身性喹吡罗阻断增强作用。喹吡罗输注在背侧纹状体并不影响母体增强和雷氯必利输注在背侧纹状体并没有扭转阻断母体增强全身喹吡罗。在给定日期第二次溶媒输注后的发声结果与初始溶媒输注后的结果无差异，因此实验设计无法解释药物输注的影响。因为背侧和腹侧纹状体灌注都增加了活动水平，所以活动水平不能解释结果。
Most mammalian infants vocalize when isolated. The vocalization promotes caregiver proximity, which is critical to survival. If, before isolation, a rat pup has contact with its dam, its isolation vocalization rate is increased (maternal potentiation) relative to isolation preceded only by littermate contact. Prior work showed that systemic administration of a D2 receptor agonist blocks maternal potentiation at doses that do not alter baseline vocalization. In this study, infusion of quinpirole (2 mu g/side) into the nucleus accumbens also blocks maternal potentiation. Infusion of the accumbens with the D2 antagonist raclopride (4 mu g/side) prevents systemic quinpirole from blocking potentiation. Quinpirole infusion in the dorsal striatum did not affect maternal potentiation and infusion of raclopride in the dorsal striatum did not reverse the block of maternal potentiation by systemic quinpirole. Vocalization results after a second vehicle infusion on a given day are no different than the results following an initial vehicle infusion, so experimental design can not account for the effects of drug infusions. Because activity level was increased by both dorsal and ventral striatum infusions, activity level can not account for the results.