C-type natriuretic peptide and its relation to non-invasive indices of left ventricular function in patients with chronic heart failure
C-type natriuretic peptide and its relation to non-invasive indices of left ventricular function in patients with chronic heart failure
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DOI：
10.1016/j.peptides.2007.10.022
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发表时间：
2008-01-01
期刊：
影响因子：
3
通讯作者：
Morales, M. A.
中科院分区：
文献类型：
--
作者：
Del Ry, S.;Maltinti, M.;Morales, M. A.
作为临床严重程度的函数，慢性心力衰竭（CHF）患者的 C 型利钠肽（CNP）显着增加。本研究的目的是评估 CHF 患者循环 CNP 浓度与左心室 (LV) 功能的回波多普勒常规指数以及 dP/dt 等负荷无关参数之间的关系。对 38 名 CHF 患者和 63 名对照者的左心室射血分数 (EF)、左心室舒张末期内径 (LVEDD) 和 LV dP/dt 以及血浆 CNP 水平进行了评估。 CHF 患者的 CNP 水平显着高于对照组（7.19 +/- 0.59 pg/ml vs. 2.52 +/- 0.12 pg/ml，p < 0.0001）。观察到 dP/dt 和 CNP 水平之间存在显着相关性 (r = -0.61，p < 0.0001)。还报道了与 EF 的良好相关性（r = -0.55，p < 0.001）和与 LVEDD 的不太显着的相关性（r = 0.316，p < 0.05）。当根据 dP/dt 值对患者进行分组时，观察到 CNP 水平非常显着的差异：I 组（600，n = 13）：分别为 8.46 +/- 0.69 和 4.75 +/- 0.75 pg/ml，p < 0.001。这是第一项报告 CHF 患者 CNP 和 dP/dt 之间相关性的研究，从而表明其可能对心肌收缩力产生影响。 (C) 2007 Elsevier Inc. 保留所有权利。
C-type natriuretic peptide (CNP) significantly increases in chronic heart failure (CHF) patients as a function of clinical severity. Aim of this study was to evaluate in CHF patients the relationship between circulating CNP concentrations and echo-Doppler conventional indices of left ventricular (LV) function as well as less load independent parameters as dP/dt. LV ejection fraction (EF), left ventricular end-diastolic dimension (LVEDD) and LV dP/dt were evaluated together with plasma CNP levels in 38 patients with CHF and in 63 controls. CNP levels resulted significantly higher in CHF patients than in controls (7.19 +/- 0.59 pg/ml vs. 2.52 +/- 0.12 pg/ml, p < 0.0001). A significant correlation between dP/dt and CNP levels (r = -0.61, p < 0.0001) was observed. A good correlation with EF (r = -0.55, p < 0.001) and a less significant relation with LVEDD (r = 0.316, p < 0.05) were also reported. When patients were divided according to dP/dt values a very significant difference in CNP levels was observed: Group I (600, n = 13): 8.46 +/- 0.69 and 4.75 +/- 0.75 pg/ml, respectively, p < 0.001. This is the first study that reports a correlation between CNP and dP/dt in CHF patients, thus suggesting a possible role on cardiac contractility. (C) 2007 Elsevier Inc. All rights reserved.