[Usefulness of hepatic arterial infusion chemotherapy for liver metastasis in gastric cancer].
[Usefulness of hepatic arterial infusion chemotherapy for liver metastasis in gastric cancer].
复制标题
肝动脉灌注化疗治疗胃癌肝转移的疗效[J].
DOI：
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
T. Monden
中科院分区：
文献类型：
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作者：
H. Takahashi;T. Tono;S. Tamagaki;A. Yasue;K. Okada;T. Kano;T. Iwazawa;S. Matsui;Y. Nakano;H. Yano;M. Kinuta;M. Matsushita;J. Okamura;T. Monden
未标记
我们对9例胃癌肝转移患者进行了肝动脉化疗。化疗药物以5-FU和顺铂为主。
结果
胃切除术后的中位生存期为600天。9例中CR 2例，PR 4例，NC 2例，PD 1例。应答率为67%。将9例患者分为2组。一组为短期生存组，包括5例生存期不超过2年的患者，另一组为长期生存组，包括4例生存期超过2年的患者。我们比较了这两组，发现两组之间的原发性病变没有差异。长期生存组患者的肝脏转移灶比短期生存组患者少且小。长期生存组患者行胃切除术时除肝转移外，无不可切除病灶。然而，短期生存组中有2例患者在进行胃切除术时有不可切除的淋巴结受累。9例中6例死于肝外病变。
结论
动脉灌注化疗对胃癌肝转移有效。然而，大多数患者死于肝外病变。因此，我们应该考虑使用全身化疗与动脉化疗。
UNLABELLED
We have performed intra-hepatic arterial chemotherapy for 9 patients with liver metastasis arising from gastric cancer. We mainly used 5-FU and CDDP as antineoplastic drugs.
RESULTS
The median survival after gastrectomy was 600 days. Of 9 cases, 2 showed CR, 4 PR, 2 NC, 1 PD. The response rate was 67%. The 9 cases were classified into 2 groups. One group, the short-term survival group, concised of 5 patients that had no more than 2 years survival and the other, the long-term survival group, consisted 4 patients that had more than 2 years survival. We compared these 2 groups and found no difference in the primary lesions between the 2 groups. The patients in the long-term survival group had fewer and smaller metastatic lesions in the liver than the patients of the short-term survival group. The patients in the long-term survival group had no unresectable lesions except liver metastasis when gastrectomy was performed. However, 2 patients in the short term survival group had unresectable lymphatic involvement at the time gastrectomy was performed. Of 9 patients, 6 died from the extrahepatic lesion.
CONCLUSION
The intra-arterial chemotherapy was effective and useful for liver metastasis arising from gastric cancer. However, the majority of patients died from extrahepatic lesions. We should therefore consider the use of systemic chemotherapy with intra-arterial chemotherapy.