Improvement of the inverse-gated-decoupling sequence for a faster quantitative analysis by 13C NMR
Improvement of the inverse-gated-decoupling sequence for a faster quantitative analysis by 13C NMR
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DOI：
10.1016/j.crci.2005.06.030
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发表时间：
2006-03-01
影响因子：
1.6
通讯作者：
Baguet, É
中科院分区：
文献类型：
--
作者：
Giraudeau, P;Wang, JL;Baguet, É
反门控解耦序列能够获得定量的 H-1 解耦 C-13 光谱。我们修改了这个顺序，以便在更短的时间内获得相同的结果。为此，我们确定了最佳的 C-13 纵向磁化初始值，以便在 H-1 解耦器停止时实现更快的弛豫。该值可以通过纵向弛豫时间和核奥沃豪泽效应计算出来。对于给定的核，H-1 解耦的补充延迟和/或恢复延迟开始时的脉冲允许加速 C-13 纵向弛豫。我们在 N,N-二甲基乙酰胺分子上检查了这一结果。对所有碳进行同步定量分析，与通常的序列相比，恢复延迟除以四。
The inverse-gated-decoupling sequence enables quantitative H-1 decoupled C-13 spectra to be obtained. We modified this sequence so as to obtain the same result in less time. For that, we determined the optimal C-13 longitudinal-magnetisation initial value for a faster relaxation while H-1 decoupler is stopped. This value can be calculated via the longitudinal relaxation times and the nuclear Overhauser effects. For a given nucleus, a supplementary delay of H-1 decoupling and/or a pulse at the beginning of the recovery delay allows an acceleration of the C-13 longitudinal relaxation. We checked this result on the molecule of N,N-dimethylacetamide. A simultaneous quantitative analysis of all carbons was carried out with a recovery delay divided by four compared to the Usual sequence.