[3H]dihydroalprenolol binding in the rat brainstem.
[3H]dihydroalprenolol binding in the rat brainstem.
复制标题
[3H]二氢阿普洛尔在大鼠脑干中的结合。
DOI：
10.1016/0014-2999(81)90078-9
复制
发表时间：
1981
影响因子：
5
通讯作者：
U'Prichard,DC
中科院分区：
文献类型：
--
作者：
Stone,EA;U'Prichard,DC
The binding of [3H]dihydroalprenolol to β-adrenergic receptors in the rat brainstem was studied. Propranolol inhibited dihydroalprenolol binding to a greater extent than did isoproterenol or epinephrine. Scatchard plots obtained with propranolol were biphasic whereas those obtained with isoproterenol and epinephrine were monophasic. The results indicate that in the brainstem propranolol displaces dihydroalprenolol from sites other than β-adrenergic receptors. Nonspecific binding of dihydroalprenolol in this tissue therefore cannot be assayed using propranolol but should be measured with isoproterenol or epinephrine.
