Relationship of childhood obesity to coronary heart disease risk factors in adulthood: The Bogalusa Heart Study
Relationship of childhood obesity to coronary heart disease risk factors in adulthood: The Bogalusa Heart Study
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DOI：
10.1542/peds.108.3.712
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发表时间：
2001-09-01
期刊：
影响因子：
8
通讯作者：
Berenson, GS
中科院分区：
文献类型：
--
作者：
Freedman, DS;Khan, LK;Berenson, GS
背景儿童期肥胖与成人期的血脂、脂蛋白、血压和胰岛素水平以及冠心病（CHD）发病率有关。然而，在这些协会的肥胖发展的年龄的重要性仍然不确定。我们评估了2617名参与者的儿童期体重指数（BMI，kg/m2）与成人血脂、胰岛素和血压水平的纵向关系。所有参与者在2至17岁时进行首次检查，并在18至37岁时进行复查;平均随访时间为17年。在超重儿童（BMI大于或等于第95百分位数）中，77%的儿童成年后仍然肥胖（>30 kg/m2）。儿童期超重与成人不良危险因素水平相关，但相关性较弱（r类似于0.1-0.3），并归因于儿童期和成年期之间体重状况的强烈持续性。虽然肥胖成人有不良水平的血脂、胰岛素和血压，但这些危险因素的水平并不随儿童体重状况或肥胖发病年龄（小于或等于8岁、12-17岁或大于或等于18岁）而变化。需要更多的数据来评估儿童期体重状况与CHD发病率的独立关系。由于体重正常的儿童成为肥胖的成年人有不利的危险因素水平，并可能会在成人发病率的风险增加，我们的研究结果强调需要一级和二级预防。
Background. Childhood obesity is related to adult levels of lipids, lipoproteins, blood pressure, and insulin and to morbidity from coronary heart disease (CHD). However, the importance of the age at which obesity develops in these associations remains uncertain.Objective and Design. We assessed the longitudinal relationship of childhood body mass index (BMI, kg/m(2)) to adult levels of lipids, insulin, and blood pressure among 2617 participants. All participants were initially examined at ages 2 to 17 years and were reexamined at ages 18 to 37 years; the mean follow-up was 17 years.Results. Of the overweight children (BMI greater than or equal to 95th percentile), 77% remained obese (>30 kg/m(2)) as adults. Childhood overweight was related to adverse risk factor levels among adults, but associations were weak (r similar to 0.1-0.3) and were attributable to the strong persistence of weight status between childhood and adulthood. Although obese adults had adverse levels of lipids, insulin, and blood pressure, levels of these risk factors did not vary with childhood weight status or with the age (less than or equal to8 years, 12-17 years, or greater than or equal to 18 years) of obesity onset.Conclusions. Additional data are needed to assess the independent relationship of childhood weight status to CHD morbidity. Because normal-weight children who become obese adults have adverse risk factor levels and probably will be at increased risk for adult morbidity, our results emphasize the need for both primary and secondary prevention.