Celecoxib pre-treatment in human colorectal adenocarcinoma patients is associated with gene expression alterations suggestive of diminished cellular proliferation
Celecoxib pre-treatment in human colorectal adenocarcinoma patients is associated with gene expression alterations suggestive of diminished cellular proliferation
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DOI：
10.1016/j.ejca.2008.05.010
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发表时间：
2008-08-01
影响因子：
8.4
通讯作者：
Mcleod, Howard L.
中科院分区：
文献类型：
--
作者：
Auman, James Todd;Church, Robert;Mcleod, Howard L.
用环氧化酶-2抑制剂塞来昔布处理的癌细胞显示出生长抑制和诱导凋亡。本研究旨在确定塞来昔布对体内治疗的人结直肠癌的影响是否与此过程相关。23例原发性结直肠腺癌患者被随机分组，在手术切除前接受7天疗程的塞来昔布（400mg b.i.d）或不服用药物。从患者队列中切除的腺癌进行基因表达谱分析。使用fold change（>1.5）和p值(
Cancer cells treated with the cyclooxygenase-2 inhibitor celecoxib show growth inhibition and induced apoptosis. This study was conducted to determine if the same processes are relevant to celecoxib's effects on human colorectal adenocarcinomas treated in vivo. A cohort of 23 patients with primary colorectal adenocarcinomas was randomised to receive a 7-d course of celecoxib (400 mg b.i.d.) or no drug prior to surgical resection. Gene expression profiling was performed on resected adenocarcinomas from the cohort of patients. Using fold change (>1.5) and p-value (