Organising multi-dimensional biological image information:: The BioImage Database
Organising multi-dimensional biological image information:: The BioImage Database
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DOI：
10.1093/nar/27.1.280
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发表时间：
1999-01-01
影响因子：
14.9
通讯作者：
Boudier, T
中科院分区：
文献类型：
--
作者：
Carazo, JM;Stelzer, EHK;Boudier, T
如今，通过获得多维图像信息，可以解开细胞组织各级的复杂信息。在大分子的狂欢，三维（3D）电子显微镜，与其他技术一起，能够达到纳米或亚纳米水平的分辨率。信息以包含给定功能的样品的3D体积的形式传递，例如，给定大分子内的电子密度分布。同样的情况也发生在细胞水平上，新形式的光学显微镜，特别是共聚焦显微镜，所有这些都产生生物3D体积信息。此外，还可以记录随时间变化的图像序列（视频）以及体积序列，从而提供有关活生物系统动态的关键信息。正是在这种背景下，生物图像的工作开始于两年前，它的第一个版本现在在这里。从本质上讲，BioImage是一个数据库，专门设计用于包含多维图像，执行查询，并在万维网上交互式地处理所产生的多维信息，以及完成所需的跨数据库链接。BioImage的两个姐妹主页可以在http://www.bioimage.org和http://www-embl.bioimage.org上访问。
Nowadays it is possible to unravel complex information at all levels of cellular organization by obtaining multi-dimensional image information. At the macromolecular revel, three-dimensional (3D) electron microscopy, together with other techniques, is able to reach resolutions at the nanometer or subnanometer level. The information is delivered in the form of 3D volumes containing samples of a given function, for example, the electron density distribution within a given macromolecule. The same situation happens at the cellular level with the new forms of light microscopy, particularly confocal microscopy, all of which produce biological 3D volume information. Furthermore, it is possible to record sequences of images over time (videos), as well as sequences of volumes, bringing key information on the dynamics of living biological systems. It is in this context that work on BioImage started two years ago, and that its first version is now presented here. In essence, BioImage is a database specifically designed to contain multi-dimensional images, perform queries and interactively work with the resulting multi-dimensional information on the World Wide Web, as well as accomplish the required cross-database links. Two sister home pages of BioImage can be accessed at http://www.bioimage.org and http://www-embl.bioimage.org.