Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend
Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend
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DOI：
10.1016/s0168-3659(02)00041-x
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发表时间：
2002-05-17
影响因子：
10.8
通讯作者：
Wnek, GE
中科院分区：
文献类型：
--
作者：
Kenawy, ER;Bowlin, GL;Wnek, GE
以盐酸四环素作为模型药物，对电纺纤维垫作为药物递送载体进行了研究。这些垫子由聚乳酸（PLA）、聚（乙烯 - 醋酸乙烯酯）（PEVA）或两者按50:50的比例混合制成。纤维是从含有少量甲醇以溶解药物的氯仿溶液中进行电纺的。通过紫外 - 可见光谱法对盐酸四环素从这些新型药物递送系统中的释放情况进行监测。将电纺垫的释放曲线与一种市售的药物递送系统Actisite®（阿尔扎公司，美国加利福尼亚州帕洛阿尔托）以及各种配方的浇铸膜进行了比较。（C）2002爱思唯尔科学出版社。版权所有。
Electrospun fiber mats are explored as drug delivery vehicles using tetracycline hydrochloride as a model drug. The mats were made either from poly(lactic acid) (PLA), poly (ethylene-co-vinyl acetate) (PEVA), or from a 50:50 blend of the two. The fibers were electrospun from chloroform solutions containing a small amount of methanol to solubilize the drug. The release of the tetracycline hydrochloride from these new drug delivery systems was followed by UV-VIS spectroscopy. Release profiles from the electrospun mats were compared to a commercially available drug delivery system, Actisite((R)) (Alza Corporation, Palo Alto, CA), as well as to cast films of the various formulations. (C) 2002 Elsevier Science B.V. All rights reserved.