Phylogenetic and Ontogenetic View of Erythroblastic Islands.
Phylogenetic and Ontogenetic View of Erythroblastic Islands.
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DOI：
10.1155/2015/873628
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发表时间：
2015
影响因子：
--
通讯作者：
Kalfa TA
中科院分区：
文献类型：
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作者：
Giger KM;Kalfa TA
成红细胞岛是哺乳动物红细胞生成的标志，其由被成熟成红细胞包围并与其密切相互作用的中央巨噬细胞组成。巨噬细胞被认为具有许多功能，如支持成红细胞增殖、为血红蛋白提供铁、促进去核和清除核碎片;此外，成红细胞岛形成的抑制通常对红细胞生成有害。巨噬细胞和微环境在红细胞生成中的作用仍有很多不了解，可以从与非哺乳动物脊椎动物中红细胞生成龛的比较分析中获得见解，与哺乳动物不同，非哺乳动物脊椎动物具有保留其核的红细胞。哺乳动物中红细胞无核的成红细胞岛的系统发育强调了巨噬细胞在成红细胞去核中的重要性。
Erythroblastic islands are a hallmark of mammalian erythropoiesis consisting of a central macrophage surrounded by and interacting closely with the maturing erythroblasts. The macrophages are thought to serve many functions such as supporting erythroblast proliferation, supplying iron for hemoglobin, promoting enucleation, and clearing the nuclear debris; moreover, inhibition of erythroblastic island formation is often detrimental to erythropoiesis. There is still much not understood about the role that macrophages and microenvironment play in erythropoiesis and insights may be gleaned from a comparative analysis with erythropoietic niches in nonmammalian vertebrates which, unlike mammals, have erythrocytes that retain their nucleus. The phylogenetic development of erythroblastic islands in mammals in which the erythrocytes are anucleate underlines the importance of the macrophage in erythroblast enucleation.