INSERTIONAL MUTAGENESIS OF THE MYC LOCUS BY A LINE-1 SEQUENCE IN A HUMAN-BREAST CARCINOMA
INSERTIONAL MUTAGENESIS OF THE MYC LOCUS BY A LINE-1 SEQUENCE IN A HUMAN-BREAST CARCINOMA
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DOI：
10.1038/333087a0
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发表时间：
1988-05-05
期刊：
影响因子：
64.8
通讯作者：
ASTRIN, SM
中科院分区：
文献类型：
--
作者：
MORSE, B;ROTHERG, PG;ASTRIN, SM
原癌基因c-myc是禽骨髓瘤病毒MC 29携带的转化序列的细胞同源物。越来越多的证据表明，原癌基因（如c-mycin）的结构和功能改变与肿瘤发生有关。在这里，我们报告的结构比较myc从导管腺癌的乳腺癌和正常乳腺组织的同一病人（Sc）揭示了一个肿瘤特异性重排的一个环和扩增的其他mycocus。（关于霉菌的观点见参考文献1-4;关于霉菌与乳腺肿瘤的关系见参考文献5-7。）重排位点的第二个内含子内有一个非myc序列，与一个长的散布的重复元件（LINE-1序列或LI）几乎完全同源。在这种情况下，L1序列作为一个移动的遗传元件产生体细胞突变。
The proto-oncogenec-mycis the cellular homologue of the transforming sequence carried by the avian myelocytomastosis virus MC29. A growing body of evidence implicates structural and functional alterations in and around proto-oncogenes such asc-mycin tumorogenesis. Here we report that comparison of the structure ofmycfrom a ductal adenocarcinoma of the breast and from normal breast tissue of the same patient (Sc) revealed a tumour-specific rearrangement of onemyclocus and amplification of the othermyclocus. (Formycreviews see refs 1–4; formycinvolvement in breast neoplasia see refs 5–7.) Within the second intron of the rearranged locus was a non-mycsequence with nearly complete homology to a long interspersed repetitive element (a LINE-1 sequence or LI). In this case, the L1 sequence has functioned as a mobile genetic element to produce a somatic mutation.