Impact of Exogenous Testosterone on Reproduction in Transgender Men.
Impact of Exogenous Testosterone on Reproduction in Transgender Men.
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DOI：
10.1210/endocr/bqaa014
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发表时间：
2020-03
期刊：
影响因子：
4.8
通讯作者：
M. Moravek;Hadrian M Kinnear;Jenny S. George;Jourdin Batchelor;A. Shikanov;V. Padmanabhan;J. Randolph
中科院分区：
文献类型：
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作者：
M. Moravek;Hadrian M Kinnear;Jenny S. George;Jourdin Batchelor;A. Shikanov;V. Padmanabhan;J. Randolph
研究表明，一部分变性男性渴望孩子;然而，关于性别肯定睾酮治疗对生殖功能的影响的文献很少。在这篇手稿中，我们将回顾跨性别男性的性别肯定激素治疗的过程，以及对跨性别男性睾丸激素暴露的卵巢和子宫后果的了解;与现有的雄激素暴露动物模型进行比较;总结现有的关于跨性别人群的育儿经验和愿望的文献;讨论辅助生殖技术和生育能力保护的考虑因素;并找出文献中的空白和进一步研究的机会。
Studies show that a subset of transgender men desire children; however, there is a paucity of literature on the effect of gender-affirming testosterone therapy on reproductive function. In this manuscript, we will review the process of gender-affirming hormone therapy for transgender men and what is known about ovarian and uterine consequences of testosterone exposure in transgender men; draw parallels with existing animal models of androgen exposure; summarize the existing literature on parenting experiences and desires in transgender people; discuss considerations for assisted reproductive technologies and fertility preservation; and identify gaps in the literature and opportunities for further research.