The epidemiology of prostate cancer in Jamaica
The epidemiology of prostate cancer in Jamaica
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DOI：
10.1016/s0022-5347(01)63220-8
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发表时间：
1998-06-01
影响因子：
6.6
通讯作者：
Walsh, PC
中科院分区：
文献类型：
--
作者：
Glover, FE;Coffey, DS;Walsh, PC
目的：在这项研究之前，世界上报告的前列腺癌发病率最高的被认为是美国黑人男性。1992年，美国黑人和白人男性的年龄调整比率分别为249/10万和182/10万。牙买加有250万人口，主要是非洲裔，对该国前列腺癌的流行病学进行了研究，并与美国白人和黑人的前列腺癌进行了比较。材料和方法：这项研究包括1989-1994年间确诊的1121例前列腺癌。信息来源包括牙买加癌症登记处、政府病理实验室、医院和诊所记录以及医生办公室记录。发病率是使用1991年牙买加人口普查的数据计算的。年龄调整采用1970年美国标准人口。结果：牙买加金斯敦经年龄调整后的前列腺癌平均发病率为304/10万男性。确诊时患者的中位年龄为72岁。超过80%的病例经病理证实。30%的患者出现急性尿潴留，16%的患者出现骨转移，15%的患者在确诊时有肉眼血尿，42%的患者有可疑癌症的异常直肠检查。1989年仅有7%的病例检测到前列腺特异性抗原，但到1994年有48%的病例检测到前列腺癌。结论：这些数据表明，金斯敦的牙买加男性前列腺癌的发病率很高，远远高于同期的美国黑人。此外，牙买加的癌症在临床上更为严重，其发病率高于美国。
Purpose: Before this study, the highest reported incidence of prostate cancer in the world was thought to be among United States black men. The age adjusted rates in 1992 for United States black and white men were 249 and 182/100,000 respectively. The epidemiology of prostate cancer in Jamaica, a country of 2.5 million people of primarily African descent, was studied and compared with that of white and black Americans.Materials and Methods: The study included 1,121 cases of prostate cancer diagnosed from 1989 to 1994. Sources of information included the Jamaican Cancer Registry, government pathology laboratory, hospital and clinic records, and physician office records. Incidence rates were computed using data from the 1991 Jamaican census. Age adjustments were made using the 1970 United States standard population.Results: The average age adjusted incidence of prostate cancer in Kingston, Jamaica was 304/100,000 men. Median patient age at diagnosis was 72 years. More than 80% of the cases were pathologically confirmed. Of the patients 30% presented with acute urinary retention, 16% presented with bone metastases, 15% had gross hematuria at the time of diagnosis and an abnormal rectal examination suspicious for cancer was noted in 42%. Prostate specific antigen was measured in only 7% of cases in 1989 but in 48% of cases by 1994.Conclusions: These data demonstrate that Jamaican men in Kingston have a high incidence of prostate cancer, much higher than even black Americans during a similar period. Furthermore, the cancers are more significant clinically with greater morbidity in Jamaica than in the United States.