STRINGENT SEQUENCE REQUIREMENTS FOR THE FORMATION OF HUMAN TELOMERES
STRINGENT SEQUENCE REQUIREMENTS FOR THE FORMATION OF HUMAN TELOMERES
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DOI：
10.1073/pnas.91.19.8861
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发表时间：
1994-09-13
影响因子：
11.1
通讯作者：
DELANGE, T
中科院分区：
文献类型：
--
作者：
HANISH, JP;YANOWITZ, JL;DELANGE, T
在人类细胞中，端粒T（2）AG（3）重复序列的转染诱导功能性端粒在先前的间质位点形成。我们报道了端粒的形成有严格的序列要求，当（T（2）AG（3））（n）端粒种子在大约70%的转染细胞中形成端粒时，五个与T（2）AG（3）相关的异源端粒DNA在细胞中接种了新的端粒。
In human cells, transfection of telomeric T(2)AG(3) repeats induces the formation of functional telomeres at previously interstitial sites. We report that telomere formation has stringent sequence requirements, While (T(2)AG(3))(n) telomere seeds formed telomeres in approximate to 70% of the transfected cells, five T(2)AG(3)-related heterologous telomeric DNAs seeded new telomeres in