To modulate or not to modulate: Differing results in uniquely shaped Williams syndrome brains
To modulate or not to modulate: Differing results in uniquely shaped Williams syndrome brains
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DOI：
10.1016/j.neuroimage.2006.05.014
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发表时间：
2006-09-01
期刊：
影响因子：
5.7
通讯作者：
Reiss, Allan L.
中科院分区：
文献类型：
--
作者：
Eckert, Mark A.;Tenforde, Adam;Reiss, Allan L.
威廉姆斯综合征(WS)的基于体素的形态计量学(VBM)研究表明，与典型对照相比，顶后灰质减少的结果非常一致。然而，WS VBM的其他发现并不一致。特别是，关于下丘脑和眶前灰质区域的不同发现已被报道。我们研究了8个WS和9个对照成人的样本，结果表明，下丘脑和眼眶前额叶皮质的结果取决于图像是否经过雅可比调制。基于形变的形态计量学(DBM)分析表明，两组之间的主要脑形状差异解释了雅可比调制灰质的发现。这些结果表明，当实验组之间存在大体形状和大小差异时，对调制灰质发现的谨慎解释是有必要的。这项研究证明了方法学选择对于理解WS这样的疾病的重要性，但也强调了这种疾病的顶叶、眶前叶和中脑结果在方法学、参与者和研究小组中的一致性。(C)2006 Elsevier Inc.保留所有权利。
Voxel based morphometry (VBM) studies of Williams syndrome (WS) have demonstrated remarkably consistent findings of reduced posterior parietal gray matter compared to typical controls. Other WS VBM findings have been inconsistent, however. In particular, different findings have been reported for hypothalamus and orbitofrontal gray matter regions. We examined a sample of 8 WS and 9 control adults and show that the hypothalamus and orbitofrontal cortex results depend on whether the images undergo Jacobian modulation. Deformation based morphometry (DBM) analysis demonstrated that major brain shape differences between the groups accounted for the Jacobian modulated gray matter findings. These results indicate that cautious interpretations of modulated gray matter findings are warranted when there are gross shape and size differences between experimental groups. This study demonstrates the importance of methodological choices towards understanding a disorder like WS, but also highlights the consistency of parietal lobe, orbitofrontal, and midbrain findings for this disorder across methodologies, participants, and research groups. (c) 2006 Elsevier Inc. All rights reserved.