NEW MEASUREMENTS FOR ASSESSMENT OF IMPAIRED CEREBRAL AUTOREGULATION USING NEAR-INFRARED SPECTROSCOPY
NEW MEASUREMENTS FOR ASSESSMENT OF IMPAIRED CEREBRAL AUTOREGULATION USING NEAR-INFRARED SPECTROSCOPY
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DOI：
10.1007/978-0-387-85998-9_41
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发表时间：
2009-01-01
期刊：
影响因子：
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通讯作者：
Van Huffel, Sabine
中科院分区：
文献类型：
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作者：
De Smet, Dominique;Vanderhaegen, Joke;Van Huffel, Sabine
有些早产儿的大脑自动调节功能较差。脑血管内氧合（HbD）（计算为氧合（HbO（2））和脱氧（Hb）血红蛋白之间的差异）与平均动脉血压（MABP）之间的一致性反映了自身调节受损。由于HbD不是绝对值，我们发展了数学来证明脑组织氧合（TOI），所有绝对信号计算为HbO（2）与总血红蛋白（Hb+HbO（2））的比值，可以取代HbD。在此期间，我们试图通过定义一个临界百分比或信号记录时间（CPRT），从理论上预测患者的自动调节的真实水平。对20例需要重症监护的早产儿进行了研究。使用NIRO-300（（c）Hamamatsu，日本）获得HbD和TOI。连续测量有创MABP。所有的数学都显示HbD和TOI之间有很强的相似性。
Some preterm infants have poor cerebral autoregulation. The concordance between cerebral intravascular oxygenation (HbD), computed as the difference between oxygenated (HbO(2)) and deoxygenated (Hb) haemoglobin, and mean arterial blood pressure (MABP) reflects impaired autoregulation. As HbD is not ail absolute value, we developed mathematics to prove that the cerebral tissue oxygenation (TOI), ail absolute signal computed as the ratio of HbO(2) to total haemoglobin (Hb+HbO(2)), may replace HbD. In the meantime, we attempt to theoretically predict the true level of autoregulation of a patient by defining a critical percentage or the signal recording time (CPRT). 20 preterm infants with need for intensive care were Studied in the first days of life. HbD and TOI were obtained with the NIRO-300 ((c) Hamamatsu, Japan). Invasive MABP was measured Continuously. All mathematics showed a strong similarity between HbD and TOI.