The German version of the chronic urticaria quality-of-life questionnaire: factor analysis, validation, and initial clinical findings
The German version of the chronic urticaria quality-of-life questionnaire: factor analysis, validation, and initial clinical findings
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DOI：
10.1111/j.1398-9995.2008.01920.x
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发表时间：
2009-06-01
期刊：
影响因子：
12.4
通讯作者：
Maurer, M.
中科院分区：
文献类型：
--
作者：
Mlynek, A.;Magerl, M.;Maurer, M.
慢性荨麻疹(CU)是一种常见的皮肤病，给患者的生活质量(QOL)造成了巨大的负担。本研究的目的是编制和验证德语版的慢性荨麻疹患者生活质量问卷(CU-Q(2)OL)，并提供对QOL的参考评估。他们还完成了两份完善的普通皮肤科QOL问卷，皮肤科生活质量指数(DLQI)和Skindex-29。因子分析用于确定德国CU-Q(2)的量表。使用DLQI和Skindex-29的相关性进行验证。因子分析确定了德国CU-Q(2)OL的6个维度：功能、睡眠、瘙痒/尴尬、精神状态、肿胀/进食和外貌限制，这6个维度解释了数据方差的70%。这六个量表中有五个具有良好的内部一致性，另外五个具有收敛的效度。在百分制范围内，他们的CU-Q(2)OL得分中值如下：29分功能正常，44分睡眠，50分瘙痒/尴尬，50分精神状态，31分肿胀/进食，31分外表限制。疾病严重程度显著地预测了所有量表的得分。年龄预示着功能、睡眠、瘙痒/尴尬和肿胀/进食。性预示着瘙痒/尴尬和眼神受限。这项研究对德国版的CU-Q(2)ol进行了有力的验证。它证实了之前的研究，即CU对生活质量有临床意义的负担，特别是对睡眠和心理健康，而且女性更严重地受到瘙痒的影响。德国CU-Q(2)醇应广泛应用于CU的临床治疗研究。
Chronic urticaria (CU) is a common skin disorder that causes a substantial burden on patients' quality-of-life (QoL). The aim of this work was to generate and validate a German version of the Chronic Urticaria Quality of Life Questionnaire (CU-Q(2)oL) and to provide reference assessments of QoL.The Italian CU-Q(2)oL was translated into German and administered to 157 CU patients. They also completed two well-established general dermatology QoL questionnaires, the Dermatology Life Quality Index (DLQI) and Skindex-29. Factor analysis was used to identify scales of the German CU-Q(2)oL. Correlation to the DLQI and Skindex-29 was used for validation. Multiple linear regression was used to determine which patient characteristics were associated with which dimensions of QoL.The factor analysis identified six scales of the German CU-Q(2)oL: functioning, sleep, itching/embarrassment, mental status, swelling/eating, and limits looks, which accounted for 70% of the data variance. Five of these six scales showed good internal consistency, and another five demonstrated convergent validity. On a percentile scale, they had these median CU-Q(2)oL scores: 29 functioning, 44 sleep, 50 itching/embarrassment, 50 mental status, 31 swelling/eating, 31 limits looks. Disease severity significantly predicted scores on all scales. Age predicted functioning, sleep, itching/embarrassment, and swelling/eating. Sex predicted itching/embarrassment and limits looks.This study yielded a robust validation of the German version of the CU-Q(2)oL. It confirmed previous studies that CU has a clinically meaningful burden on QoL, especially for sleep and mental health, and that women are more severely affected by pruritus. The German CU-Q(2)oL should be widely adopted in clinical research on the treatment of CU.