Neocortical atrophy, third ventricular width, and cognitive dysfunction in multiple sclerosis
Neocortical atrophy, third ventricular width, and cognitive dysfunction in multiple sclerosis
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DOI：
10.1001/archneur.63.9.1301
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发表时间：
2006-09-01
影响因子：
--
通讯作者：
Zivadinov, Robert
中科院分区：
文献类型：
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作者：
Benedict, Ralph H. B.;Bruce, Jared M.;Zivadinov, Robert
背景：认知功能障碍在多发性硬化症（MS）中很常见。报告萎缩与神经心理学测试结果之间的相关性。目的：确定在预测神经心理损伤时新皮质体积是否会取代或补充第三脑室宽度和其他磁共振成像测量。设计：横断面研究。地点：大学多发性硬化症诊所。参与者：77 名复发缓解型多发性硬化症患者、42 名继发进展型多发性硬化症患者和 27 名健康对照受试者。主要结果指标：脑萎缩和脑萎缩对所有患者进行了病变负荷测量。 82 名患者和所有对照患者的子集接受了神经心理学测试。结果：继发进展性 MS 患者比复发缓解型 MS 患者和对照患者有更多的萎缩。新皮质体积与所有神经心理学测量值显着相关，r 值范围为 0.29 至 0.58。在大多数逐步回归分析中，第三脑室宽度被保留，用于预测 MS 患者的认知障碍，并区分 MS 的继发进展和复发缓解病程。结论：我们证实了 MS 中新皮质体积与多个认知域之间的关联，尽管新皮质体积并不能解释比其他磁共振成像测量显着更多的差异。在所研究的磁共振成像变量中，大多数回归模型保留了第三心室宽度。
Background: Cognitive dysfunction is common in multiple sclerosis (MS). Correlations are reported between atrophy and neuropsychological test results.Objective: To determine if neocortical volume would supplant or supplement third ventricular width and other magnetic resonance imaging measures when predicting neuropsychological impairment.Design: Cross-sectional study.Setting: University MS clinic.Participants: Seventy-seven patients with relapsing-remitting MS, 42 patients with secondary progressive MS, and 27 healthy control subjects.Main Outcome Measures: Brain atrophy and lesion burden measures were obtained in all patients. A subset of 82 patients and all controls underwent neuropsychological testing.Results: Patients with secondary progressive MS had more atrophy than patients with relapsing-remitting MS and controls. Neocortical volume was significantly correlated with all neuropsychological measures, with r values ranging from 0.29 to 0.58. Third ventricular width was retained in most stepwise regression analyses predicting cognitive impairment in patients with MS and distinguishing secondary progressive from relapsing-remitting courses of MS.Conclusions: We confirm an association between neocortical volume and multiple cognitive domains in MS, although neocortical volume did not explain significantly more variance than other magnetic resonance imaging measures. Of the magnetic resonance imaging variables studied, third ventricular width was retained in most regression models.