OSMOTIC CHANGES CAUSED BY ACCUMULATION OF DULCITOL IN LENSES OF RATS FED WITH GALACTOSE
OSMOTIC CHANGES CAUSED BY ACCUMULATION OF DULCITOL IN LENSES OF RATS FED WITH GALACTOSE
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DOI：
10.1038/1941085a0
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发表时间：
1962-01-01
期刊：
影响因子：
64.8
通讯作者：
MEROLA, LO
中科院分区：
文献类型：
--
作者：
KINOSHITA, JH;DIKMAK, E;MEROLA, LO
在维持高半乳糖或木糖饮食或通过四氧嘧啶注射的大鼠中实验产生的白内障具有相似的临床表现1。由于这些白内障的发展和外观相似，因此建议可能涉及共同的机制或因素。我们想知道货车Heyningen首次观察到的多元醇积累是否可能是这些白内障的起始因素。多元醇与酮糖沿着在透镜纤维中的蓄积可能足以产生渗透干扰。由于光活性物质的增加，水将被吸入透镜纤维中。由于糖，特别是糖醇，不容易通过生物膜扩散，它们的浓度可能达到足以增加水的体积的水平，从而引起透镜纤维膨胀，并可能使它们的膜破裂。
CATARACTS produced experimentally in rats maintained on a diet high in galactose or xylose or by alloxan injection have similar clinical manifestations1. Since the development and appearance of these cataracts are similar, there is the suggestion that a common mechanism or factor may be involved. We wondered whether the accumulation of polyols first observed by van Heyningen2,3might possibly be the initiating factor in these cataracts. It seemed possible that the accumulation of polyols, along with the keto sugars, in the lens fibres might be sufficient to create an osmotic disturbance. Because of the increase in the osmotically active substances, water would be drawn into the lens fibres. Since sugars, especially the sugar alcohols, do not readily diffuse through biological membranes, their concentrations might reach a level which would increase the volume of water sufficiently to cause the lens fibres to swell and perhaps to rupture their membranes.