MICROVASCULARITY IN BENIGN PROSTATIC HYPERPLASIA
MICROVASCULARITY IN BENIGN PROSTATIC HYPERPLASIA
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DOI：
10.1002/pros.2990260302
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发表时间：
1995-03-01
期刊：
影响因子：
2.8
通讯作者：
BRAWER, MK
中科院分区：
文献类型：
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作者：
DEERING, RE;BIGLER, SA;BRAWER, MK
良性前列腺增生（BPH）的血管密度尚未得到表征。之前我们报道过前列腺癌的血管密度（w/mm（2））是正常前列腺的两倍[Bigler等人：Pathol 24：220-226 1993]。为了进一步描述良性前列腺组织中的血管密度，我们检查了15例通过开放性前列腺切除术获得的BPH。血管用抗凝血因子VIII相关抗原的抗体染色，血管密度用计算机辅助图像分析进行测量，血管密度在不同组织学类型之间进行分析。所有移行区组织的平均血管密度为70.2 vv/mm（2）。上皮增生结节中的血管密度（平均值99.3，SD 40.7）与前列腺癌中的血管密度（平均值101.4，SD 35.6）相似。上皮结节中的血管密度显著高于非结节上皮组织（平均76.7，SD 23.1; P < 0.001，比值= 1.3）。高细胞间质结节中的血管密度（平均64.7，SD 19.1）高于相邻间质区域（平均36.5，SD 15.3; P < 0.001，比值= 1.8）。总的来说，前列腺增生的血管密度高于以前在根治性前列腺切除术标本中测量的良性组织中发现的，特别是在结节状形态的区域。(C)1995年Wiley-Liss，Inc.
The vascular density of benign prostatic hyperplasia (BPH) has not been characterized. Previously we reported vessel density (w/mm(2)) in prostatic carcinoma was twice that of normal prostate [Bigler et al.: Hum Pathol 24:220-226 1993]. To further characterize vessel density in benign prostate tissue we examined 15 cases of BPH obtained by open prostatectomy. Vessels were stained with antibodies to Factor VIII-related antigen, and vessel density was measured using computer-assisted image analysis.Vessel density was analyzed between various histologic tissue types. Mean vessel density in all transition zone tissue was 70.2 vv/mm(2). Vessel density in epithelial hyperplastic nodules (mean 99.3, SD 40.7) exhibited density levels similar to those found in prostatic carcinoma (mean 101.4, SD 35.6). Vessel density in epithelial nodules was significantly higher than in non-nodular epithelial tissue (mean 76.7, SD 23.1; P < 0.001, ratio = 1.3). Higher vessel densities were found in hypercellular stromal nodules (mean 64.7, SD 19.1) than in adjacent stromal areas (mean 36.5, SD 15.3; P < 0.001, ratio = 1.8). Overall, vessel density in BPH was higher than previously found in benign tissue measured in radical prostatectomy specimens, especially in areas of nodular morphology. (C) 1995 Wiley-Liss, Inc.