Oscillatory dynamics mechanism induced by protein synthesis time delay in quorum-sensing system
Oscillatory dynamics mechanism induced by protein synthesis time delay in quorum-sensing system
复制标题
群体感应系统中蛋白质合成时间延迟引起的振荡动力学机制
DOI：
10.1103/physreve.99.062405
复制
发表时间：
2019-06-10
影响因子：
2.4
通讯作者：
Yan, Fang
中科院分区：
文献类型：
--
作者：
Chen, Menghan;Liu, Haihong;Yan, Fang
最近的实验证据表明，群体感应的振荡行为在细菌合成和释放抗癌药物的过程中发挥着极其重要的作用。我们知道，AIIA、Luxi、内部AHL、外部AHL、AHL底物和H_2O_2六种物质是群体感应系统的核心部分。这里，本文基于普林德尔等人提出的描述上述六种物质相互作用的数学模型的一部分，从理论上研究了时延、可变的H_2O_2、鲁西诱导的AHL合成速率和AIIA诱导的AHL降解率等几个重要因素对群体感应系统振荡行为的影响。[自然508,387(2014)]。结果表明，时滞是群体感应系统产生振荡的前提条件。此外，时延的长短可以决定振荡的幅度和周期。此外，H_2O_2浓度的变化会引起群体感应系统的振荡行为。此外，在H_2O_2的调节下，群体感应系统的周期稳健性也同样增强，当鲁西诱导的AHL合成速率低于某一临界值时，除非呈现稳定状态，否则群体感应系统呈现周期振荡。此外，AIIA诱导的过高或过低的AHL降解率都不会引起群体感应系统的振荡，只有中间水平才会引起振荡。最后，给出了群体感应系统振荡行为的两参数和三参数区域。
Recent experimental evidence reports that the oscillatory behavior of quorum sensing plays an extremely important role in the process of bacterial synthesis and release drug to fight cancer. As we know, the six substances AiiA, LuxI, internal AHL, external AHL, AHL substrate, and H2O2 are the core parts of the quorum-sensing system. Here, the effects of several important factors, including time delay, variable H2O2, AHL synthesis rate induced by LuxI, and AHL degradation rate induced by AiiA on the oscillatory behavior of the quorum-sensing system are studied theoretically based on a part of mathematical model describing the interaction of the above six substances proposed by Prindle et al. [Nature 508, 387 (2014)]. The results show that the time delay is a prerequisite for inducing oscillation of the quorum-sensing system. Furthermore, the length of time delay can determine the amplitude and period of oscillation. As a further matter, the change of H2O2 concentration can induce the oscillatory behavior of the quorum-sensing system. In addition, under the regulation of H2O2, the period robustness of the quorum-sensing system is increased Similarly, the quorum-sensing system exhibits periodic oscillation when AHL synthesis rate induced by LuxI less than a certain critical value, unless it displays a steady state. Additionally, a too-high or too-low level of AHL degradation rate induced by AiiA will fail to generate oscillation of the quorum-sensing system, only the intermediate level will cause oscillation. Finally, the two and three parameter regions in which the quorum-sensing system exhibits oscillation behavior are generated.