unc-1:: A stomatin homologue controls sensitivity to volatile anesthetics in Caenorhabditis elegans
unc-1:: A stomatin homologue controls sensitivity to volatile anesthetics in Caenorhabditis elegans
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DOI：
10.1073/pnas.95.15.8761
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发表时间：
1998-07-21
影响因子：
11.1
通讯作者：
Morgan, PG
中科院分区：
文献类型：
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作者：
Rajaram, S;Sedensky, MM;Morgan, PG
为了确定挥发性麻醉剂的作用位点，我们正在研究线虫中控制挥发性麻醉剂敏感性的功能途径中的基因。unc-1基因在该途径中占据中心位置。unc-1的不同等位基因对不同挥发性麻醉药的敏感性有独特的影响。STO-1与人stomatin具有广泛的同源性，stomatin是一种被认为调节相关离子通道的膜蛋白。我们推测，在C.并且可能代表挥发性麻醉剂的分子靶点。
To identify sites of action of volatile anesthetics, we are studying genes in a functional pathway that controls sensitivity to volatile anesthetics in the nematode Caenorhabditis elegans. The unc-1 gene occupies a central position in this pathway. Different alleles of unc-1 have unique effects on sensitivity to the different volatile anesthetics. UNC-1 shows extensive homology to human stomatin, an integral membrane protein thought to regulate an associated ion channel. We postulate that UNC-1 has a direct effect on anesthetic sensitivity in C. elegans and may represent a molecular target for volatile anesthetics.