Defining structural homology between the mammalian and avian hippocampus through conserved gene expression patterns observed in the chick embryo
Defining structural homology between the mammalian and avian hippocampus through conserved gene expression patterns observed in the chick embryo
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DOI：
10.1016/j.ydbio.2012.03.027
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发表时间：
2012-06-15
影响因子：
2.7
通讯作者：
Sen, Jonaki
中科院分区：
文献类型：
--
作者：
Gupta, Sandeep;Maurya, Reshma;Sen, Jonaki
哺乳动物海马体是成人大脑的神经发生中心，参与学习和记忆处理等关键功能。尽管鸟类和哺乳动物的大脑海马区总体功能保守，但存在一些形态差异。已经提出了一些不同的模型来识别鸟类和哺乳动物海马之间的区域和结构同源性，但尚未达成共识。在这项研究中，我们在分子水平上系统、全面地描述了发育中的鸡海马体。我们确定了海马发育过程中神经发生和凋亡的时间窗口，以及鸡海马腹侧V形区神经元可能的起源和迁移路径。除此之外，我们还发现了鸡和小鼠海马体中表达模式保守的几个基因。我们的研究提供的分子数据部分支持文献中报道的鸟类和哺乳动物海马结构同源性的模型之一。本研究中发现的在发育中的鸡海马体中特异性表达的基因的功能特征可能为调节鸟类海马体发育的机制提供有价值的信息，并且或许也可以推断到哺乳动物海马体的发育。 (C) 2012 Elsevier Inc. 保留所有权利。
The mammalian hippocampus, a center of neurogenesis in the adult brain, is involved in critical functions such as learning and memory processing. Although there is an overall functional conservation between birds and mammals in the hippocampal region of the brain, there are several morphological differences. A few different models have been proposed for identifying regional and structural homology between the avian and mammalian hippocampus however a consensus is yet to be reached. In this study we have systematically and comprehensively characterized the developing chicken hippocampus at the molecular level. We have identified the time window of neurogenesis and apoptosis during hippocampal development as well as the likely origin and migration path of neurons of the ventral v-shaped region of chick hippocampus. In addition to this we have identified several genes with expression patterns that are conserved between the hippocampus of chicken and mice. Our study provides molecular data that partially supports one of the models reported in literature for structural homology between the avian and mammalian hippocampus. Functional characterization of the genes found in this study to be specifically expressed in the developing chicken hippocampus is likely to provide valuable information on the mechanisms regulating hippocampus development of birds and perhaps could be extrapolated to mammalian hippocampus development as well. (C) 2012 Elsevier Inc. All rights reserved.