Parcellation of the human substantia nigra based on anatomical connectivity to the striatum
Parcellation of the human substantia nigra based on anatomical connectivity to the striatum
复制标题
DOI：
10.1016/j.neuroimage.2013.05.043
复制
发表时间：
2013-11-01
期刊：
影响因子：
5.7
通讯作者：
Duezel, Emrah
中科院分区：
文献类型：
--
作者：
Chowdhury, Rumana;Lambert, Christian;Duezel, Emrah
由多巴胺能投射到纹状体定义的黑质/腹侧被盖区（SN/VTA）亚区受到健康（如正常衰老）和疾病（如帕金森病）的不同影响。这可能会对依赖于多巴胺能区域和回路的奖励处理产生影响。我们对30名健康老年人进行了弥散张量成像（DTI）和概率神经束造影，以确定是否可以根据与纹状体的解剖连通性来描绘SN/VTA的亚区。我们发现SN/VTA的背内侧区域优先连接到腹侧纹状体，而更腹外侧的区域连接到背侧纹状体。这些SN/VTA亚区可以通过定量结构成像参数的差异来表征，表明不同的潜在组织特性。我们还观察到这些连接模式不同地映射到奖励依赖人格特质。我们发现，神经束造影可用于将SN/VTA分割成解剖学上合理且行为上有意义的隔室，这种方法可能有助于未来的研究提供更细粒度的多巴胺能中脑病理变化及其功能影响的概述。(C) 2013年作者。Elsevier Inc.出版。版权所有。
Substantia nigra/ventral tegmental area (SN/VTA) subregions, defined by dopaminergic projections to the striatum, are differentially affected by health (e.g. normal aging) and disease (e.g. Parkinson's disease). This may have an impact on reward processing which relies on dopaminergic regions and circuits. We acquired diffusion tensor imaging (DTI) with probabilistic tractography in 30 healthy older adults to determine whether subregions of the SN/VTA could be delineated based on anatomical connectivity to the striatum. We found that a dorsomedial region of the SN/VTA preferentially connected to the ventral striatum whereas a more ventrolateral region connected to the dorsal striatum. These SN/VTA subregions could be characterised by differences in quantitative structural imaging parameters, suggesting different underlying tissue properties. We also observed that these connectivity patterns differentially mapped onto reward dependence personality trait. We show that tractography can be used to parcellate the SN/VTA into anatomically plausible and behaviourally meaningful compartments, an approach that may help future studies to provide a more fine-grained synopsis of pathological changes in the dopaminergic midbrain and their functional impact. (C) 2013 The Authors. Published by Elsevier Inc. All rights reserved.