Dermatosis-arthritis syndrome associated with Crohn's disease in a teenager
Dermatosis-arthritis syndrome associated with Crohn's disease in a teenager
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DOI：
10.1016/j.revmed.2006.07.017
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发表时间：
2006-11-01
影响因子：
0.9
通讯作者：
Aubin, F.
中科院分区：
文献类型：
--
作者：
Guerre-Schmidt, A. -R.;Pelletier, F.;Aubin, F.
导论. - 脓疱病、结节性红斑、关节炎和全身表现与皮肤病-关节炎综合征相关。它是肠-回肠-空肠分流术的一种公认的并发症，但也与炎症性肠病有关。- 我们报告的情况下，青少年谁提出了皮肤病关节炎综合征与克罗恩病在介绍脓疱病，结节性红斑和发热。这种进化因断肛而变得复杂。结肠镜检查和肠道活检发现克罗恩病。皮肤和肠道症状迅速改善与全身皮质类固醇。- 皮肤病-关节炎综合征可能与肠旁路术和炎症性肠病有关，溃疡性结肠炎比克罗恩病更常见。它包括水疱脓疱性皮疹、结节性红斑、发热、关节炎和眼部表现。组织学与Sweet综合征有很大的相似性。生理病理学涉及微生物增殖、针对皮肤的免疫复合物的形成以及中性粒细胞和增强因子的活化和迁移。治疗以皮质类固醇和非类固醇抗炎药或氨苯砜为基础。(C)2006年爱思唯尔马森SAS。吨储备。
Introduction. - Pustulosis, erythema nodosum, arthritis and systemic manifestations are associated in the dermatosis-arthritis syndrome. It is a well recognized complication of the bowel ileo-jejunal bypass but it is also associated with inflammatory bowel diseases.Exegese. - We report the case of an adolescent who presented with a dermatosis-arthritis syndrome associated to a Crohn's disease during a referring for pustulosis, erythema nodosum and fever. The evolution is complicated by proctorragia. Colonoscopy and intestinal biopsy found a Crohn's disease. Cutaneous and intestinal symptoms quickly improved with systemic corticosteroids.Conclusion. - The dermatosis-arthritis syndrome can be associated with bowel bypass and with inflammatory bowel disease, more frequently with ulcerative colitis than with Crohn's disease. It consists in a vesiculopustular eruption, erythema nodosum, fever, arthritis and ocular manifestations. Histopathology bears a strong resemblance with Sweet's syndrome. Physiopathology implicates microbial proliferation, formation of immune complex against skin and activation and migration of neutrophils and increasing factors. The treatment is based on corticosteroids and non steroid anti-inflammatory drugs or dapsone. (C) 2006 Elsevier Masson SAS. Tons droits reserves.