Independent regulation of hair and skin color by two G protein-coupled pathways
Independent regulation of hair and skin color by two G protein-coupled pathways
复制标题
两种 G 蛋白耦合途径独立调节头发和皮肤颜色
DOI：
10.1111/j.1755-148x.2009.00609.x
复制
发表时间：
2009-12-01
影响因子：
4.3
通讯作者：
Ito, Shosuke
中科院分区：
文献类型：
--
作者：
Van Raamsdonk, Catherine D.;Barsh, Gregory S.;Ito, Shosuke
在哺乳动物中，毛发的颜色和皮肤的颜色经常是协调一致的.为了探索这一点，我们研究了两种不同的G蛋白偶联途径的突变，每一种都会影响头发和皮肤颜色的黑暗程度。在每个小鼠突变体（GnaqDsk1，Gna11Dsk7和Mc1re）中，我们分析了黑素细胞密度以及毛发或皮肤中真黑素（黑色色素）和褐黑素（黄色色素）的浓度，以确定调节色素沉着的机制。令人惊讶的是，我们发现每个突变对头发和皮肤颜色的影响都不同。此外，我们还发现，在表皮中，黑皮质素信号通路并不像在毛囊中那样将真黑素与褐黑素的合成偶联。即使通过共享的信号通路，毛发和皮肤黑素细胞也是相当独立地调节的。
P>Hair color and skin color are frequently coordinated in mammalian species. To explore this, we have studied mutations in two different G protein coupled pathways, each of which affects the darkness of both hair and skin color. In each mouse mutant (GnaqDsk1, Gna11Dsk7, and Mc1re), we analyzed the melanocyte density and the concentrations of eumelanin (black pigment) and pheomelanin (yellow pigment) in the hair or skin to determine the mechanisms regulating pigmentation. Surprisingly, we discovered that each mutation affects hair and skin color differently. Furthermore, we have found that in the epidermis, the melanocortin signaling pathway does not couple the synthesis of eumelanin with pheomelanin, as it does in hair follicles. Even by shared signaling pathways, hair and skin melanocytes are regulated quite independently.