Hematoporphyrin derivative phototherapy in the treatment of bronchogenic carcinoma.
Hematoporphyrin derivative phototherapy in the treatment of bronchogenic carcinoma.
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DOI：
10.1378/chest.86.1.8
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发表时间：
1984-07
期刊：
影响因子：
9.6
通讯作者：
D. Cortese;J. Kinsey
中科院分区：
文献类型：
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作者：
D. Cortese;J. Kinsey
19例涉及气管支气管树的癌症患者（共20例癌症）已完成至少一个疗程的血卟啉衍生物光疗，通过柔性纤维支气管镜给药。7例患者（8例癌）显示完全缓解。在这些患者中的6例（7例癌）中，在随访8至31个月期间，治疗部位没有肿瘤复发。1例患者完全缓解，持续12个月，但随后局部复发，导致梗阻;该患者在最初的血卟啉衍生物光疗后24个月死亡。另外8名患者的反应不完全，需要替代治疗。这8例患者中有3例死亡，1例死于转移，2例死于气道阻塞和转移。其余4名患者在评估这种局部治疗的结果之前死亡; 2名死于转移，2名死于咯血。完全缓解患者的癌症表面积小于3平方厘米，在支气管镜检查时表现为浅表性。因此，血卟啉衍生物光疗确实有可能成为手术切除的替代方案，作为精心选择的患者的主要治疗方法。
Nineteen patients with cancer involving the tracheobronchial tree (a total of 20 carcinomas) have completed at least one course of hematoporphyrin derivative phototherapy administered via the flexible fiberoptic bronchoscope. Seven patients (eight carcinomas) have shown a complete response. In six of these patients (seven carcinomas), there has been no recurrence of tumor at the site of treatment during follow-up ranging from 8 to 31 months. One patient had a complete response lasting 12 months, but subsequently had a local recurrence producing obstruction; this patient died 24 months after the initial hematoporphyrin derivative phototherapy. Eight other patients had less than a complete response and required alternative therapy. Three of these eight patients died, one of metastases and two of airway obstruction and metastases. The four remaining patients died before results of this local therapy could be assessed; two died of metastases and two of hemoptysis. The cancers in patients who had a complete response were less than 3 sq cm in surface area and appeared superficial at bronchoscopy. Therefore, hematoporphyrin derivative phototherapy does have the potential to become an alternative to surgical resection as the primary treatment in carefully selected patients.