Conjugated linoleic acid prevents the development of essential hypertension in spontaneously hypertensive rats
Conjugated linoleic acid prevents the development of essential hypertension in spontaneously hypertensive rats
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DOI：
10.1016/j.bbrc.2004.08.139
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发表时间：
2004-10-15
影响因子：
3.1
通讯作者：
Yanagita, T
中科院分区：
文献类型：
--
作者：
Inoue, N;Nagao, K;Yanagita, T
共轭亚油酸（CLA）是存在于牛肉、羊肉和乳制品中的亚油酸的位置异构体和几何异构体的混合物。在过去的几十年里，CLA吸引了相当多的关注，因为它具有潜在的有益生物学作用，包括对几种癌症，动脉粥样硬化和肥胖的保护作用。在以前的研究中，我们提供了证据表明，饮食CLA可以防止肥胖动物肥胖相关的高血压的发展。在这里，我们表明，CLA抑制自发性高血压大鼠（SHR）的非肥胖原发性高血压的发展。喂养CLA 4周后，与喂养亚油酸的大鼠相比，收缩压的升高被显著抑制。在CLA喂养的SHR中，腹部脂肪组织重量也显著降低。花生四烯酸，类花生酸生产的底物的含量，没有改变。但油酸的积累，脂肪生成的最终产物，显着减少在膜磷脂的CLA喂养的SHR。此外，我们还发现，CLA喂养的SHR血浆脂联素水平升高，这可能是高血压的一个调节因子，其机制可能是通过提高mRNA表达实现的。我们推测CLA的降压作用可能是通过提高血浆脂联素水平，减轻膜异常而实现的。(C)2004年爱思唯尔公司All rights reserved.
Conjugated linoleic acid (CLA) is a mixture of positional and geometric isomers of linoleic acid found in beef, lamb, and dairy products. CLA has attracted considerable attention over the past several decades because of its potentially beneficial biologic effects, including protective effects against several cancers, atherosclerosis, and obesity. In previous studies, we provided evidence that dietary CLA could prevent the development of obesity-related hypertension in obese animals. Here, we show that CLA suppresses the development of non-obese essential hypertension in spontaneously hypertensive rats (SHRs). After 4 weeks of feeding with CLA, the increase of systolic blood pressure was significantly suppressed compared with rats fed linoleic acid. Abdominal adipose tissue weight was also significantly lowered in CLA-fed SHRs. Content of arachidonic acid, the substrate of eicosanoid production, was not changed. but accumulation of oleic acid, the lipogenesis end-product, was markedly decreased in the membrane phospholipids of CLA-fed SHRs. In addition, we found increased level of plasma adiponectin, suggested as a regulatory factor of hypertension, through the enhancement of mRNA expression in CLA-fed SHRs. We speculate that the antihypertensive effect of dietary CLA may be due to the increase of plasma adiponectin level and associated with the alleviation of membrane abnormality in SHRs. (C) 2004 Elsevier Inc. All rights reserved.