Exercise training provides cardioprotection via a reduction in reactive oxygen species in rats submitted to myocardial infarction induced by isoproterenol
Exercise training provides cardioprotection via a reduction in reactive oxygen species in rats submitted to myocardial infarction induced by isoproterenol
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DOI：
10.1080/10715760903159154
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发表时间：
2009-01-01
影响因子：
3.3
通讯作者：
De Souza, Claudio T.
中科院分区：
文献类型：
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作者：
Frederico, Marisa J. S.;Justo, Simoni L.;De Souza, Claudio T.
运动训练已证明有保护心脏的作用。然而，这种效应背后的确切机制尚不清楚。本研究评估了先前12周的跑步机训练对异丙肾上腺素（ISO）致梗死大鼠心肌氧化损伤水平、抗氧化酶活性和损伤的影响。与生理盐水对照组（生理盐水）相比，异丙肾上腺素治疗组（80 mg/kg，分2次等量给予2天）在最后一次注射后24 h内出现心律失常，死亡率为60%。C + ISO组小鼠心肌肌酸激酶- MB水平明显升高。12周的跑步机训练减少了这些动物的超氧化物生成、脂质过氧化水平和蛋白质羰基化，同时增加了SOD和CAT的活性和表达。以前的训练也减少了40%的CK-MB水平和死亡人数，防止了ISO的有害影响。本研究数据提示，12周的跑步机训练可提高雄性大鼠心脏抗氧化酶水平，减少氧化损伤，降低ISO引起的心肌梗死程度。
Exercise training has demonstrated cardioprotection effects. However, the exact mechanism behind this effect is not is clear. The present study evaluated the effects of 12 weeks of previous treadmill training on the levels of oxidative damage, antioxidant enzyme activity and injury in the myocardium of rats submitted to infarction induced by isoproterenol (ISO). Isoproterenol treatment (80 mg/kg given over 2 days in two equal doses) caused arrhythmias and 60% mortality within 24 h of the last injection in the control group (C + ISO) group when compared with the saline control group (saline). Creatine Kinase - MB levels were markedly increased in hearts from ISO-treated animals in the C + ISO group. Twelve weeks of treadmill training reduced superoxide production, lipid peroxidation levels and protein carbonylation in these animals, as well as increasing the activities and expressions of SOD and CAT. Previous training also reduced CK-MB levels and numbers of deaths by 40%, preventing the deleterious effects of ISO. Based on the data obtained in this study, it is suggested that 12-week treadmill training increases antioxidant enzymes, decreases oxidative damage and reduces the degree of infarction induced by ISO in the hearts of male rats.