Influence of androgens and pituitary hormones on the structural profile and secretory activity of the lacrimal gland.
Influence of androgens and pituitary hormones on the structural profile and secretory activity of the lacrimal gland.
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DOI：
10.1111/j.1600-0420.1996.tb00594.x
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发表时间：
2009-05
期刊：
影响因子：
--
通讯作者：
D. Sullivan;L. Block;J. Pena
中科院分区：
文献类型：
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作者：
D. Sullivan;L. Block;J. Pena
本研究旨在研究雄激素对多种物种泪腺的大小、形态外观以及液体和蛋白质分泌能力的影响。为了进行比较，我们还试图确定其他激素是否可以刺激该组织的生长和分泌能力。从完整的、手术操作和/或激素处理的大鼠、小鼠、豚鼠和兔子获得泪腺和泪液，并进行组织学和/或图像分析技术处理。我们的结果表明：1）雄激素调节大鼠泪腺组织的超微结构特征； 2) 雄激素可能影响体重、形态和泪腺分泌，然而，这些影响在小鼠、大鼠、豚鼠和兔子中并不统一，而是取决于物种和/或动物的内分泌状态； 3)用睾酮、催乳素、生长激素、α-黑素细胞刺激激素、胰岛素或甲状腺素加地塞米松治疗对垂体切除的雄性大鼠泪腺的绝对或相对大小或泪液量没有影响。总的来说，这些发现表明雄激素可以调节泪腺的结构和分泌。然而，这种激素作用的性质和程度取决于物种，并且可能会因内分泌环境的改变而改变。
The present study was designed to examine the influence of androgens on the size, morphological appearance, and fluid and protein secretory capacity of the lacrimal gland in a variety of species. For comparison, we also sought to determine whether other hormones might stimulate the growth and secretory ability of this tissue. Lacrimal glands and tears were obtained from intact, surgically-operated and/or hormone-treated rats, mice, guinea pigs and rabbits and the processed for histological and/or image analysis techniques. Our results demonstrated that: 1) androgens modulate the ultrastructural features of rat lacrimal tissue; 2) androgens may influence the weight, morphological aspects, and secretion of the lacrimal gland, however, these effects are not uniform in mice, rats, guinea pigs and rabbits, but instead are dependent upon the species and/or the animal's endocrine status; and 3) treatment with testosterone, prolactin, growth hormone, alpha-melanocyte stimulating hormone, insulin, or thyroxine plus dexamethasone had no impact on the absolute or relative size of the lacrimal gland, or the tear volume, of hypophysectomized male rats. Overall, these findings indicate that androgens may regulate the structure and secretion of the lacrimal gland. However, the nature and extent of this hormone action is species-dependent and may be modified by alterations in the endocrine environment.