Single-nucleotide polymorphisms of matrix metalloproteinases and their inhibitors in gastrointestinal cancer
Single-nucleotide polymorphisms of matrix metalloproteinases and their inhibitors in gastrointestinal cancer
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DOI：
10.4251/wjgo.v3.i6.79
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发表时间：
2011-06-15
影响因子：
3
通讯作者：
Sier, Cornelis F. M.
中科院分区：
文献类型：
--
作者：
Langers, Alexandra M. J.;Verspaget, Hein W.;Sier, Cornelis F. M.
基质金属蛋白酶(MMPs)与肿瘤的发生、发展密切相关，与预后密切相关。MMPs的单核苷酸多态(SNPs)，最常位于基因的启动子区域，已被证明影响癌症的易感性和/或进展。研究了消化道肿瘤中基质金属蛋白酶-1、-2、-3、-7、-8、-9、-12、-13和-21以及金属蛋白酶组织抑制因子(TIMP)TIMP-1和TIMP-2的SNPs。本文就这些基因多态性在胃肠道肿瘤发病风险和预后中的作用作一综述。(C)2011年白石登。版权所有。
Matrix metalloproteinases (MMPs) are implicated in cancer development and progression and are associated with prognosis. Single-nucleotide polymorphisms (SNPs) of MMPs, most frequently located in the promoter region of the genes, have been shown to influence cancer susceptibility and/or progression. SNPs of MMP-1, -2, -3, -7, -8, -9, -12, -13 and -21 and of the tissue inhibitor of metalloproteinases (TIMPs) TIMP-1 and TIMP-2 have been studied in digestive tract tumors. The contribution of these polymorphisms to the cancer risk and prognosis of gastrointestinal tumors are reviewed in this paper. (C) 2011 Baishideng. All rights reserved.