Nonalcoholic fatty liver disease is associated with significant coronary artery disease in type 2 diabetic patients: A computed tomography angiography study
Nonalcoholic fatty liver disease is associated with significant coronary artery disease in type 2 diabetic patients: A computed tomography angiography study
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DOI：
10.1111/1753-0407.12172
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发表时间：
2015-03-01
影响因子：
4.5
通讯作者：
Karcaaltincaba, Musturay
中科院分区：
文献类型：
--
作者：
Idilman, Ilkay S.;Akata, Deniz;Karcaaltincaba, Musturay
背景：研究非酒精性脂肪性肝病（NAFLD）是否与2型糖尿病患者冠状动脉疾病（CAD）相关，这些患者接受了冠状动脉计算机断层血管造影（CTA）。方法2007年6月至2010年5月，273例无已知肝病的2型糖尿病患者因胸痛接受冠状动脉CTA治疗。轴向、多平面和最大强度投影（MIP）图像用于确定心血管疾病。肝脂肪含量由未增强的CT图像测量，用于钙评分。当平均肝衰减值为40 Hounsfield Unit （HU）时，定义为中度和重度NAFLD。结果273例患者中，76% （n=207）的患者患有CAD；48%的患者冠脉CTA有明显的冠心病（50例狭窄）。冠心病患者年龄较大，以男性为主。CT计算肝脏平均衰减值为5012 HU。代谢综合征患者的平均肝脏衰减值低于无代谢综合征患者(P
BackgroundTo investigate whether nonalcoholic fatty liver disease (NAFLD) is associated with coronary artery disease (CAD) in type 2 diabetic patients, who underwent coronary computed tomography angiography (CTA).MethodsBetween June 2007 and May 2010, a total of 273 type 2 diabetic patients without known liver disease underwent coronary CTA for chest pain were enrolled. Axial, multiplanar, and Maximum intensity projection (MIP) images were used for determining the cardiovascular disease. Liver fat content was measured from unenhanced CT images obtained for calcium scoring. Moderate and severe NAFLD was defined when mean liver attenuation value is 40 Hounsfield Unit (HU).ResultsAmong 273 patients, 76% of the patients (n=207) had CAD; 48% of them had significant CAD (50 stenosis) by coronary CTA. Patients with CAD were older and male gender was predominant. Mean liver attenuation value calculated with CT was 5012 HU. Mean liver attenuation value was lower in patients with metabolic syndrome compared to patients without metabolic syndrome (P