Tyrosine-derived polycarbonate membrane in treating mandibular bone defects.: An experimental study
Tyrosine-derived polycarbonate membrane in treating mandibular bone defects.: An experimental study
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DOI：
10.1098/rsif.2006.0119
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发表时间：
2006-10-22
影响因子：
3.9
通讯作者：
Suuronen, Riitta
中科院分区：
文献类型：
--
作者：
Asikainen, Antti J.;Noponen, Jukka;Suuronen, Riitta
本研究旨在评估一种新型生物可吸收材料在骨缺损治疗中的适用性。采用聚去氨基酪氨酸-酪氨酸-碳酸乙酯（PDTE碳酸酯）膜（厚度0.2-0.3 mm）植入20只新西兰大白兔下颌角，覆盖12 × 6 mm的贯通缺损。1组缺损不填充，用膜覆盖；2组缺损用生物活性玻璃网填充，也用膜覆盖。控制装置没有盖上，也没有填充。分别随访6周、12周、24周和52周。通过组织学反应和新生骨的定性分析对材料进行评价。我们发现PDTE在组织中引起了适度的异物反应，这在整个研究中是一致的。六周后，所有样本都有新骨形成。第1组新骨形成较多，直至24周，此后差异逐渐消除。本研究结果表明，PDTE碳酸酯膜具有良好的生物相容性，无需额外的支持基质即可促进骨生长。
This study was designed to evaluate the suitability of a novel bioabsorbable material in treating bone defects. A poly(desaminotyrosyl-tyrosine-ethyl ester carbonate) (PDTE carbonate) membrane (thickness 0.2-0.3 mm) was implanted into the mandibular angle of 20 New Zealand White rabbits to cover a through-and-through defect (12 x 6 mm). In group 1, the defects were left unfilled but covered with membrane and in group 2 the defects were filled with bioactive glass mesh and covered with membrane, too. Controls were left uncovered and unfilled. The animals were followed for 6, 12, 24 and 52 weeks, respectively. The material was evaluated by qualitative analysis of histological reactions and newly formed bone.We found that PDTE carbonate elicited a modest foreign body reaction in the tissues, which was uniform throughout the study. New bone formation was seen in all samples after six weeks. Group 1 had more new bone formation until 24 weeks and after this the difference settled. Based on findings of this study it was concluded that PDTE carbonate membranes have good biocompatibility and are sufficient to enhance bone growth without additional supportive matrix.