DRUSEN AND THEIR RELATIONSHIP TO SENILE MACULAR DEGENERATION
DRUSEN AND THEIR RELATIONSHIP TO SENILE MACULAR DEGENERATION
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DOI：
10.1111/j.1442-9071.1980.tb01670.x
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发表时间：
1980-01-01
期刊：
影响因子：
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通讯作者：
SARKS, SH
中科院分区：
文献类型：
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作者：
SARKS, SH
本研究以512只眼的临床病理检查为基础。随着老年性黄斑变性的发展，玻璃体似乎在稠度上发生了变化，变得更多的液体。这导致了一系列的临床表现，被归类为硬的、半固体的、软的或浆液性的和退化的。组织学上，玻璃样变为浅色的无定形物质，电子显微镜显示由囊泡组成。这种膜性碎片首先出现在正常老年眼的色素上皮下，但后来积累导致基底膜广泛的浅层分离。玻璃体软化在组IV最为明显，在该组首次发现视网膜下新生血管。此时视网膜色素上皮也表现出最强的增殖活性，并形成异常的基底膜物质。
This study is based on the clinico‐pathological examination of 512 eyes. As senile macular degeneration developed drusen appeared to alter in consistency and become more fluid. This resulted in a spectrum of clinical appearances classified as hard, semisolid, soft or serous, and regressing. Histologically the hyaline contents of the drusen changed to a pale‐staining amorphous material which electron microscopy showed to consist of vesicles. This membranous debris first appeared beneath the pigment epithelium in normal aged eyes but its later accumulation led to a widespread shallow separation of the basement membrane.The softening of drusen was most evident in group IV in which subretinal neovascularization was first detected. At this stage the retinal pigment epithelium also showed its greatest proliferative activity and the formation of abnormal basement membrane material.