Vitamin B6 metabolism in liver and liver-derived tumors.
Vitamin B6 metabolism in liver and liver-derived tumors.
复制标题
维生素 B6 在肝脏和肝源性肿瘤中的代谢。
作者：
N. Meisler;L. Nutter;J. W. Thanassi
维生素B6代谢已经在几个高分化和高分化的Morris肝癌中进行了研究。比较了两种低分化的Morris肝癌，宿主肝脏取自荷瘤动物，以及胎鼠、新生儿和成年大鼠的肝脏。所有Morris肝癌的吡哆醛磷酸含量、吡哆醇激酶和吡哆醇磷酸氧化酶活性均显著低于成年宿主和对照肝脏，一般落在胎儿和新生儿肝脏的测定范围内。磷酸吡哆醇磷酸酶的活性没有明显的相似规律。相对于对照和宿主肝脏，肝癌组织中依赖于磷酸吡哆醛(PLP)的酶--鸟氨酸脱羧酶的活性普遍升高。地塞米松在引起PLP依赖的肿瘤酪氨酸转氨酶活性升高的剂量下，对PLP代谢没有影响。数据表明，莫里斯肝癌与维生素b6代谢相关的肿瘤进展属于肿瘤发育模式，其特征是组织中PLP的数量减少，将前体维生素形式代谢为PLP的能力减弱。
Vitamin B6 metabolism has been investigated in several highly and well-differentiated Morris hepatomas. Comparisons have been made with two poorly differentiated Morris hepatomas, with host livers obtained from tumor-bearing animals, and with fetal, neonatal, and adult rat liver. The pyridoxal phosphate content and the activities of pyridoxine kinase and pyridoxine phosphate oxidase of all Morris hepatomas examined were significantly less than those in adult host or control livers and generally fell in the range determined for fetal and neonatal liver. A similar pattern was not evident for the activity of pyridoxine phosphate phosphatase. Relative to control and host livers, the activity in hepatomas of the pyridoxal phosphate (PLP)-dependent enzyme, ornithine decarboxylase, was generally elevated. Dexamethasone, at a dose which caused an elevation in the activity of PLP-dependent tumor tyrosine aminotransferase, had no effect on PLP metabolism. The data indicate that tumor progression in the Morris hepatoma spectrum in relation to vitamin b6 metabolism falls into an onco-developmental pattern characterized by a diminished amount of tissue PLP and a diminished capability to metabolize precursor vitamer forms to PLP.
Morris 肝癌中维生素 B6 的代谢。
DOI：
--
发表时间：
1981
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Thanassi,JW;Nutter,LM;Meisler,NT;Commers,P;Chiu,JF
通讯作者：
Chiu,JF