Recent randomized trials of chemoradiation in the management of locally advanced head and neck cancer
Recent randomized trials of chemoradiation in the management of locally advanced head and neck cancer
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DOI：
10.1097/00001622-199805000-00007
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发表时间：
1998-05-01
影响因子：
3.4
通讯作者：
Adelstein, David J.
中科院分区：
文献类型：
--
作者：
Adelstein, David J.
同步化疗和放疗（或称放化疗）的使用已成为鳞状细胞头颈癌患者治疗中日益关注的焦点。比较单独放疗与同时给予放疗和单一化疗药物的随机试验表明，几种不同的药物有益处。考虑到预期的额外毒性，随机多药放化疗试验的尝试性稍稍有所提高。尽管如此，已有多项研究报道，并且观察到放化疗具有更一致的生存获益。使用快速交替化疗和放疗方案的治疗方案也提高了生存率。尽管这些积极的治疗方法会产生显着的发病率，并且可能并不适合所有患者，但放化疗在这种疾病的明确治疗中的作用正在被确定。
The use of concurrent chemotherapy and radiation, or chemoradiation, has become the focus of increasing interest in the management of patients with squamous-cell head and neck cancer. Randomized trials comparing radiation therapy alone with radiation and single chemotherapeutic agents given concurrently have suggested benefit for several different drugs. Randomized multiagent chemoradiotherapeutic trials have been approached somewhat more tentatively in view of the anticipated additional toxicity. Nonetheless, several studies have been reported, and a more consistent survival benefit with chemoradiotherapy has been observed. Treatment regimens using rapidly alternating chemotherapy and radiation schedules have also resulted in an improvement in survival. Although these kinds of aggressive treatment approaches produce significant incidences of morbidity and may not be appropriate for all patients, a role for chemoradiotherapy in the definitive management of this disease is being defined.