Nipah virus: A recently emergent deadly paramyxovirus
Nipah virus: A recently emergent deadly paramyxovirus
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DOI：
10.1126/science.288.5470.1432
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发表时间：
2000-05-26
期刊：
影响因子：
56.9
通讯作者：
Mahy, BWJ
中科院分区：
文献类型：
--
作者：
Chua, KB;Bellini, WJ;Mahy, BWJ
在马来西亚和新加坡，一种名为尼帕病毒的副粘病毒已被确定为与猪密切接触的人群中暴发严重脑炎的病原体。1998年9月下旬首次发现疫情，到1999年6月中旬，马来西亚报告了265例脑炎病例，包括105例死亡，新加坡报告了11例脑炎或呼吸道疾病病例，其中1例死亡。电镜、血清学和遗传学研究表明，该病毒属于副粘病毒科，与最近发现的亨德拉病毒关系密切。我们认为，这两种病毒是副粘病毒科内的一个新属的代表。就像亨德拉病毒。尼帕病毒在副粘病毒中是不寻常的，它能够感染包括人类在内的许多宿主物种并引起潜在的致命疾病。
A paramyxovirus virus termed Nipah virus has been identified as the etiologic agent of an outbreak of severe encephalitis in people with close contact exposure to pigs in Malaysia and Singapore. The outbreak was first noted in late September 1998 and by mid-June 1999, more than 265 encephalitis cases, including 105 deaths, had been reported in Malaysia, and 11 cases of encephalitis or respiratory illness with one death had been reported in Singapore. Electron microscopic, serologic, and genetic studies indicate that this virus belongs to the family Paramyxoviridae and is mast closely related to the recently discovered Hendra virus. We suggest that these two viruses are representative of a new genus within the family Paramyxoviridae. Like Hendra virus. Nipah virus is unusual among the paramyxoviruses in its ability to infect and cause potentially fatal disease in a number of host species, including humans.