Oral and Craniofacial Stem Cells: An Untapped Source for Neural Tissue Regeneration.
Oral and Craniofacial Stem Cells: An Untapped Source for Neural Tissue Regeneration.
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DOI：
10.1089/ten.tea.2020.0023
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发表时间：
2020-03
影响因子：
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通讯作者：
M. Marinković;Nicholas F. Dybdal-Hargreaves;T. Block;D. Dean;C. Yeh;Xiao-Dong Chen
中科院分区：
文献类型：
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作者：
M. Marinković;Nicholas F. Dybdal-Hargreaves;T. Block;D. Dean;C. Yeh;Xiao-Dong Chen
神经组织再生仍然是实现组织工程前景的一个棘手的障碍。虽然神经生物学致力于揭示控制神经元生长和修复的机制，但仍然存在相当大的技术差距，阻碍了进展。其中最主要的是缺乏适当的培养环境来忠实地体外复制神经元龛。我们认为，口腔中发现的各种多能细胞可能是一种重要的，但未充分利用的资源，用于制备这种神经源性微环境。与神经组织的细胞群一样，这些细胞群是外胚层来源的，并且具有临床证明的神经原性潜力。虽然缺乏共识，是否推定类型的口腔和颅面干细胞构成不同的人群，他们的神经组织工程的贡献可能是双重的：作为一个细胞的原料neoneurogenesis和生产专门的体外环境神经分化，表型维持，并在治疗应用。
Nerve tissue regeneration continues to represent an intractable obstacle to realizing the promise of tissue engineering. While neurobiology works to shed light on the mechanisms governing neuronal growth and repair, considerable technical gaps remain that hinder progress. Chief among these is the absence of an appropriate culture environment to faithfully reproduce the neuronal niche ex vivo. We propose that the various multipotent cells found in the oral cavity may represent an important, yet underutilized resource for preparing such neurogenic microenvironments. Like those of nerve tissue, these cell populations are of ectodermal origin and have clinically demonstrated neurogenic potential. While there is a lack of consensus on whether putative types of oral and craniofacial stem cells constitute distinct populations, their contribution to neural tissue engineering may be two-fold: as a cellular feedstock for neoneurogenesis and for the production of specialized in vitro environments for neurogenic differentiation, phenotype maintenance, and use in therapeutic applications.