Visual-tactile processing in primary somatosensory cortex emerges before cross-modal experience
Visual-tactile processing in primary somatosensory cortex emerges before cross-modal experience
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DOI：
10.1002/syn.21958
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发表时间：
2017-06-01
期刊：
影响因子：
2.3
通讯作者：
Hanganu-Opatz, Ileana L.
中科院分区：
文献类型：
--
作者：
Bieler, Malte;Sieben, Kay;Hanganu-Opatz, Ileana L.
假定的unisensory新皮质区处理多感觉信息的振荡夹带神经元网络通过直接的皮质-皮质的预测。虽然新生儿单峰的经验已被确定为必要的建立多感觉处理的神经元网络，它仍然不清楚是否早期的跨通道的经验同样控制多感觉处理的个体发育。在这里，我们评估的视觉-体感相互作用和它们的解剖基板的发展进行细胞外记录在体内的初级感觉皮层的网络活动，并评估在有色大鼠的皮质-皮质连接。与成年动物相似，具有最小交叉模态经验的幼年大鼠显示诱发反应的超加性增强，功率的时间依赖性调制和网络振荡的相位重置响应于交叉模态光和胡须刺激。此外，在视觉-触觉刺激后，单个神经元的神经元放电与θ和α网络振荡的耦合更强。幼年大鼠的多感觉加工依赖于丰富的视觉-躯体感觉直接联系和丘脑皮层前馈相互作用。因此，细胞和网络的相互作用，确保多感官处理出现之前，跨模态的经验和完善在青少年的发展。
The presumptive unisensory neocortical areas process multisensory information by oscillatory entrainment of neuronal networks via direct cortico-cortical projections. While neonatal unimodal experience has been identified as necessary for setting up the neuronal networks of multisensory processing, it is still unclear whether early cross-modal experience equally controls the ontogeny of multisensory processing. Here, we assess the development of visual-somatosensory interactions and their anatomical substrate by performing extracellular recordings of network activity in primary sensory cortices in vivo and assessing the cortico-cortical connectivity in pigmented rats. Similar to adult animals, juvenile rats with minimal cross-modal experience display supra-additive augmentation of evoked responses, time-dependent modulation of power and phase reset of network oscillations in response to cross-modal light and whisker stimulation. Moreover, the neuronal discharge of individual neurons is stronger coupled to theta and alpha network oscillations after visual-tactile stimuli. The adult-like multisensory processing of juvenile rats relies on abundant direct visual-somatosensory connections and thalamocortical feedforward interactions. Thus, cellular and network interactions ensuring multisensory processing emerge before cross-modal experience and refine during juvenile development.