Chemical genetic screening of KRAS-based synthetic lethal inhibitors for pancreatic cancer.
Chemical genetic screening of KRAS-based synthetic lethal inhibitors for pancreatic cancer.
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DOI：
10.2741/3421
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发表时间：
2009-01-01
期刊：
影响因子：
--
通讯作者：
Cheng X
中科院分区：
文献类型：
--
作者：
Ji Z;Mei FC;Lory PL;Gilbertson SR;Chen Y;Cheng X
Pancreatic cancer is one of the deadliest diseases largely due to difficulty in early diagnosis and the lack of effective treatments. KRAS is mutated in more than 90% of pancreatic cancer patients, and oncogenic KRAS contributes to pancreatic cancer tumorigenesis and progression. In this report, using an oncogenic KRASV12-based pancreatic cancer cell model, we developed a chemical genetic screen to identify small chemical inhibitors that selectively target pancreatic cancer cells with gain-of-function KRAS mutation. After screening ∼3,200 compounds, we identified one compound that showed selective synthetic lethality against the KRASV12 transformed human pancreatic ductal epithelial cell over its isogenic parental cell line. These selective KRASV12-synthetic lethal compounds may serve as leads for subsequent development of clinically-effective treatments for pancreatic cancer.
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影响因子：
4.8
作者：
Ji, Zhenyu;Mei, Fang C.;Cheng, Xiaodong
通讯作者：
Cheng, Xiaodong
影响因子：
50.3
作者：
Hingorani, SR;Wang, LF;Tuveson, DA
通讯作者：
Tuveson, DA
影响因子：
50.3
作者：
Hingorani, SR;Petricoin, EF;Tuveson, DA
通讯作者：
Tuveson, DA
影响因子：
2.2
作者：
Nociari, MM;Shalev, A;Russo, C
通讯作者：
Russo, C
影响因子：
56.9
作者：
Lamb, Justin;Crawford, Emily D.;Golub, Todd R.
通讯作者：
Golub, Todd R.