Increased cortical atrophy in patients with Alzheimer's disease and type 2 diabetes mellitus
Increased cortical atrophy in patients with Alzheimer's disease and type 2 diabetes mellitus
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DOI：
10.1136/jnnp.2005.069583
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发表时间：
2006-03-01
影响因子：
11
通讯作者：
Scheltens, P
中科院分区：
文献类型：
--
作者：
Biessels, GJ;De Leeuw, FE;Scheltens, P
背景：2型糖尿病（DM 2）患者患阿尔茨海默病（AD）的风险增加。这种风险增加归因于血管合并症，但也涉及其他机制，例如大脑加速老化。目的：确定DM 2患者的AD是否与大脑血管病变发生率增加有关，通过增加脑萎缩，或两者的组合。方法：总共有29例AD和DM 2患者和58例AD和非DM 2患者被纳入研究。记录临床特征，并进行神经心理学检查和磁共振成像（MRI）扫描。MRI扫描被评为皮质和皮质下萎缩，内侧颞叶萎缩，白色物质病变，和infarcts.Results：两组的神经心理概况是相同的。与非DM 2组相比，AD和DM 2患者在MRI上的皮质萎缩增加（p < 0.05）。此外，梗死更常见（比值比2.4; 95% CI 0.8 - 7.8），但这种影响不能解释萎缩增加。其他MR措施之间没有差异groups.Conclusion：结果表明，非血管机制，导致增加皮质萎缩，也参与了AD的风险增加DM 2。
Background: The risk of Alzheimer's disease ( AD) is increased in type 2 diabetes (DM2). This increased risk has been attributed to vascular comorbidity, but other mechanisms, such as accelerated ageing of the brain, have also been implicated.Objective: To determine whether AD in patients with DM2 is associated with an increased occurrence of vascular lesions in the brain, by increased cerebral atrophy, or a combination of both.Methods: In total, 29 patients with AD and DM2 and 58 patients with AD and without DM2 were included in the study. Clinical characteristics were recorded, and a neuropsychological examination and magnetic resonance imaging (MRI) scan were performed. MRI scans were rated for cortical and subcortical atrophy, medial temporal lobe atrophy, white matter lesions, and infarcts.Results: The neuropsychological profiles of the two groups were identical. Patients with AD and DM2 had increased cortical atrophy on MRI (p < 0.05) compared with the non-DM2 group. In addition, infarcts were more common ( odds ratio 2.4; 95% CI 0.8 to 7.8), but this effect did not account for the increased atrophy. The other MR measures did not differ between the groups.Conclusion: The results suggest that non-vascular mechanisms, leading to increased cortical atrophy, are also involved in the increased risk of AD in DM2.