INADEQUATE MATERNAL VASCULAR-RESPONSE TO PLACENTATION IN PREGNANCIES COMPLICATED BY PREECLAMPSIA AND BY SMALL-FOR-GESTATIONAL-AGE INFANTS
INADEQUATE MATERNAL VASCULAR-RESPONSE TO PLACENTATION IN PREGNANCIES COMPLICATED BY PREECLAMPSIA AND BY SMALL-FOR-GESTATIONAL-AGE INFANTS
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DOI：
10.1111/j.1471-0528.1986.tb07830.x
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发表时间：
1986-10-01
期刊：
影响因子：
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通讯作者：
BROSENS, I
中科院分区：
文献类型：
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作者：
KHONG, TY;DEWOLF, F;BROSENS, I
母体血管对胎盘反应的检查显示，胎盘床的生理变化通常从蜕膜延伸到子宫内膜。在先兆子痫和小胎龄婴儿（SGA）的怀孕比例的生理变化仅限于个别节段单独。此外，在子痫前期和SGA中，一些螺旋动脉的整个长度完全没有生理变化。这一新的观察结果在一项对异常妊娠胎盘基底板的研究中得到证实。在子痫前期和SGA的妊娠晚期，胎盘床螺旋动脉中可见腔内血管内滋养细胞，而在正常妊娠中，这一特征在妊娠中期之后才会出现。这些发现指出，在子痫前期和SGA中，迁移滋养细胞和母体子宫组织之间的正常相互作用存在缺陷。
An examination of the maternal vascular response to placentation shows that physiological changes in the placental bed normally extend from the decidua into the inner myometrium. In pre-eclampsia and in a proportion of pregnancies with small-for-gestational age infants (SGA) the physiological changes are restricted to the decidual segments alone. In addition, complete absence of physiological changes throughout the entire length of some spiral arteries is seen in pre-eclampsia and SGA. This new observation is confirmed in a study of basal plates of placentas from abnormal pregnancies. Intraluminal endovascular trophoblast may be seen in the placental bed spiral arteries in the third trimester in pre-eclampsia and SGA, a feature not seen beyond the second trimester in normal pregnancy. These findings point to a defect in the normal interaction between migratory trophoblast and maternal uterine tissues in pre-eclampsia and in SGA.