Mechanisms of histone H3 lysine 27 trimethylation remodeling during early mammalian development
Mechanisms of histone H3 lysine 27 trimethylation remodeling during early mammalian development
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DOI：
10.4161/epi.21615
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发表时间：
2012-09-01
期刊：
影响因子：
3.7
通讯作者：
Ross, Pablo J.
中科院分区：
文献类型：
--
作者：
Bogliotti, Yanina S.;Ross, Pablo J.
在受精过程中，哺乳动物生物体中两种最分化的细胞，精子和卵母细胞，结合形成多能胚胎。染色质结构的动态变化允许这些特化细胞上的染色质转变为能够产生每种细胞类型的胚胎构型。最初，这种重编程活性是由卵子发生过程中积累的卵母细胞衍生因子作为蛋白质和mRNA支持的;然而，控制它的潜在分子机制仍然缺乏表征。组蛋白H3赖氨酸27位的三甲基化（H3 K27 me 3）是一种抑制性表观遗传标记，在小鼠、牛和猪胚胎的着床前发育过程中动态变化。在这里，我们提出的数据和假说背后的H3 K27 me 3重塑早期发展的潜在机制。我们假设抑制性H3 K27 me 3标记从亲本基因组中被全面删除，以消除配子表观遗传程序并建立多能胚胎表观基因组。我们讨论的信息收集在小鼠，猪和牛，提供一个比较分析的目的，在早期哺乳动物发育过程中的表观遗传标记的重编程。
During fertilization, two of the most differentiated cells in the mammalian organism, a sperm and oocyte, are combined to form a pluripotent embryo. Dynamic changes in chromatin structure allow the transition of the chromatin on these specialized cells into an embryonic configuration capable of generating every cell type. Initially, this reprogramming activity is supported by oocyte-derived factors accumulated during oogenesis as proteins and mRNAs; however, the underlying molecular mechanisms that govern it remain poorly characterized. Trimethylation of histone H3 at lysine 27 (H3K27me3) is a repressive epigenetic mark that changes dynamically during pre-implantation development in mice, bovine and pig embryos. Here we present data and hypotheses related to the potential mechanisms behind H3K27me3 remodeling during early development. We postulate that the repressive H3K27me3 mark is globally erased from the parental genomes in order to remove the gametic epigenetic program and to establish a pluripotent embryonic epigenome. We discuss information gathered in mice, pigs, and bovine, with the intent of providing a comparative analysis of the reprogramming of this epigenetic mark during early mammalian development.