Hair cycle-dependent changes of alkaline phosphatase activity in the mesenchyme and epithelium in mouse vibrissal follicles
Hair cycle-dependent changes of alkaline phosphatase activity in the mesenchyme and epithelium in mouse vibrissal follicles
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DOI：
10.1111/j.1440-169x.2007.00907.x
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发表时间：
2007-04-01
影响因子：
2.5
通讯作者：
Matsuzaki, Takashi
中科院分区：
文献类型：
--
作者：
Iida, Machiko;Ihara, Setsunosuke;Matsuzaki, Takashi
碱性磷酸酶（ALP）活性在小鼠触须毛囊的限制性间充质和上皮区域。它的位置和强度在毛发周期中发生了巨大的变化。在毛乳头（DP）的活动是中等的，在非常早期的生长期，达到最高水平，在生长中期后DP的近端区域下降，并保持在一个低水平，在退行期。延髓真皮鞘仅在生长初期表现出强烈的ALP活性。虽然大多数球上皮细胞没有显示ALP活性，但与ALP阴性DP细胞相邻的萌发表皮细胞在生长期中期变为ALP阳性，并在单层中重排，以便在中期退行期包裹DP。在退化期，球上皮的最外层变为碱性磷酸酶阳性，这可能是滤泡上皮的前体细胞从隆突迁移。在毛形成开始前，球上皮ALP活性迅速下降，DP活性上升。这种ALP表达的动态变化可能与DP在毛发诱导中的作用有关，也可能与毛发周期中延髓结构的重建有关。
Alkaline phosphatase (ALP) activity was detected in the restricted mesenchymal and epithelial regions in mouse vibrissal follicles. Its localization and strength dramatically changed during the hair cycle. Activity in the dermal papilla (DP) was moderate in very early anagen, reached a maximal level in early anagen, decreased at the proximal region of DP after mid anagen, and was kept at a low level during catagen. The bulbar dermal sheath showed intense ALP activity only in early anagen. Although most bulbar epithelium did not show ALP activity, germinative epidermal cells that were adjacent to the ALP-negative DP cells became ALP-positive in mid anagen and rearranged in a single layer so as to encapsulate the DP in mid catagen. During catagen, the outermost layer of bulbar epithelium became ALP-positive, which could be follicular epithelial precursors migrating from the bulge. Before the initiation of hair formation, ALP activity in the bulbar epithelium rapidly decreased and that in DP increased. These dynamic changes of ALP expression might be related to DP's functions in hair induction and also to reconstruction of the bulbar structure during the hair cycle.