Arterial stiffness during hyperglycemia in older adults with high physical activity vs low physical activity
Arterial stiffness during hyperglycemia in older adults with high physical activity vs low physical activity
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DOI：
10.3164/jcbn.19-32
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发表时间：
2019-09-01
影响因子：
2.4
通讯作者：
Hashiguchi, Takeo
中科院分区：
文献类型：
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作者：
Kobayashi, Ryota;Sato, Kaori;Hashiguchi, Takeo
我们比较了糖耐量受损的活跃和不活跃老年人摄入葡萄糖后的动脉僵硬度，并阐明了体力活动是否与摄入葡萄糖后的动脉僵硬度有关。采用横断面设计对 20 名糖耐量受损的老年人进行了分析。根据国际体育活动问卷，参与者被分为活跃组（每日步数：10,175.9 +/- 837.8 步/天，n = 10）或不活跃组（每日步数：4,125.6 +/- 485.9 步/天，n = 10）。与基线相比，在不活动组（而非活动组）进行 75 g 口服葡萄糖耐量试验后，臂踝（全身）和心臂（主动脉）脉搏波速度和心踝血管指数（全身）在 30、60 和 90 分钟时较基线有所增加。在两组中进行 75 g 口服葡萄糖耐量试验后，心臂脉搏波速度与基线相比均没有变化。臂踝脉搏波速度曲线下面积与日常生活活动（r = -0.577，p = 0.008）、每日步数活动（r = 0.546，p = 0.013）和每日步数（r = -0.797，p = 0.0001）相关。目前的研究结果表明，体力活动或不活动与摄入葡萄糖后的动脉僵硬度有关。
We compared arterial stiffness after glucose intake in active and inactive elderly people with impaired glucose tolerance and clarified whether physical activity was associated with arterial stiffness after ingestion of glucose. Twenty older adults with impaired glucose tolerance were analyzed in a cross-sectional design. Based on the international physical activity questionnaire, participants were divided into the active group (daily step count: 10,175.9 +/- 837.8 steps/day, n = 10) or the inactive group (daily step count: 4,125.6 +/- 485.9 steps/day, n = 10). Brachial-ankle (systemic) and heart-brachial (aortic) pulse wave velocity and cardio-ankle vascular index (systemic) were increased at 30, 60, and 90 min compared to baseline after a 75-g oral glucose tolerance test in the inactive but not the active group. Heart-brachial pulse wave velocity did not change compared to baseline after a 75-g oral glucose tolerance test in either group. The area under the curve for brachial-ankle pulse wave velocity was associated with daily living activity (r = -0.577, p = 0.008), daily step activity (r = 0.546, p = 0.013), and the daily step count (r = -0.797, p = 0.0001). The present findings indicate that physical activity or inactivity is associated with arterial stiffness following glucose ingestion.