Diminishing returns from mutation supply rate in asexual populations
Diminishing returns from mutation supply rate in asexual populations
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DOI：
10.1126/science.283.5400.404
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发表时间：
1999-01-15
期刊：
影响因子：
56.9
通讯作者：
Lenski, RE
中科院分区：
文献类型：
--
作者：
de Visser, JAGM;Zeyl, CW;Lenski, RE
如果遗传适应通常受到突变供应的限制，那么具有增加的突变率的突变基因型在微生物进化中可能特别重要。在大肠杆菌的实验种群中，只有在小种群或最初适应良好的种群的特定情况下，进化适应率才与突变供应率成正比。这些实验还证明了无性种群适应性进化的“速度限制”，这与突变供应率无关。
Mutator genotypes with increased mutation rates may be especially important in microbial-evolution if genetic adaptation is generally Limited by the supply of mutations. In experimental populations of the bacterium Escherichia coli, the rate of evolutionary adaptation was proportional to the mutation supply rate only in particular circumstances of small or initially well-adapted populations. These experiments also demonstrate a "speed limit" on adaptive evolution in asexual populations, one that is independent of the mutation supply rate.