Silver nanoparticles modified nanocapsules for ultrasonically activated drug delivery
Silver nanoparticles modified nanocapsules for ultrasonically activated drug delivery
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DOI：
10.1016/j.msec.2012.07.006
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发表时间：
2012-12-01
影响因子：
7.9
通讯作者：
Raichur, Ashok M.
中科院分区：
文献类型：
--
作者：
Anandhakumar, S.;Mahalakshmi, V.;Raichur, Ashok M.
通过聚电解质层层组装（LbL）设计了新型超声敏感纳米胶囊，用于生物分子/药物的远程激活释放。通过在二氧化硅模板上交替组装聚（烯丙基胺盐酸盐）（PAH）和硫酸葡聚糖（DS），然后合成纳米颗粒，随后去除模板，从而产生在壁中嵌入有银纳米颗粒的纳米胶囊。银NP在受控条件下在胶囊壁内原位合成。发现纳米胶囊分散良好，并且银纳米颗粒均匀地分布在壳内。由于在NP形成过程中产生的孔，FITC-葡聚糖容易渗透到含有银NP的胶囊中。当对装载的纳米胶囊进行超声处理时，壳结构中存在的银纳米颗粒导致壳破裂成更小的碎片，从而释放出FITC-葡聚糖。这种纳米胶囊有可能被用作药物递送载体，并为现代医学，材料科学和生物化学领域的进一步发展提供了空间。(C)2012爱思唯尔有限公司版权所有。
Novel ultrasound-sensitive nanocapsules were designed via layer-by-layer assembly (LbL) of polyelectrolytes for remote activated release of biomolecules/drug. Nanocapsules embedded with silver nanoparticles in the walls were synthesized by alternate assembly of poly(allylamine hydrochloride) (PAH) and dextran sulfate (DS) on silica template followed by nanoparticle synthesis and subsequent template removal thus yielding nanocapsules. The silver NPs were synthesized in situ within the capsule walls under controlled conditions. The nanocapsules were found to be well dispersed and the silver NPs were evenly distributed within the shell. FITC-dextran permeated easily into the capsules containing silver NP's due to the pores generated during the formation of NP's. When the loaded nanocapsules were sonicated, the presence of the silver NPs in the shell structure led to rupturing of the shell into smaller fragments thus releasing the FITC-dextran. Such nanocapsules have the potential to be used as drug delivery vehicles and offer the scope for further development in the areas of modern medicine, material science, and biochemistry. (C) 2012 Elsevier B.V. All rights reserved.